Effect of Vitamin D Supplementation on Blood Glucose Homeostasis, BMI and Lipid Profile in Diabetic Patients with Vitamin D Deficiency (original) (raw)
Related papers
Therapeutic Applications of Vitamin D Supplementation on Type 2 Diabetes
Background: Many studies have found that vitamin D deficiency is associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM). This study investigated the effects of vitamin D3 supplementation on serum HbA1c values and 25(OH) vitamin D concentrations in healthy and diabetic individuals. Methods: 722 individuals aged from 36 to 61 years old were selected (360 males and 362 females) divided into two groups. Healthy male group consisted of 180 person with HbA1c value (6.78 ± 2.14) and 180 persons diagnosed with type 2 diabetes (HbA1c 11.64 ± 3.85). The healthy female group had also 180 person (HbA1c 7.42 ± 2.86) and 182 diabetic females (HbA1c 11.43 ± 2.88). Each group was then divided into two subgroups. One supplemented with (2000 IU/day) of vitamin D for 90 days and the other one was not given any vitamin D supplements. HbA1c and serum 25(OH) vitamin D were recorded. Results: Mean serum HbA1c values for both males and females improved with vitamin D supplementations but the improvement was significant in the diabetic group (males and females) comparing with healthy group. Serum HbA1c in healthy group improved by 4.8% and 2.7% for males and females respectively whereas serum HbA1c for diabetic group declined by 13.4% and 21.8% for group 7 - 9 and 9.6 and 22.1% for group > 9 for males and females respectively. Also, serum 25(OH) vitamin D concentrations improved dramatically with supplementation in healthy and diabetic groups. 25(OH) vitamin D for the healthy males improved by 67.9% and for healthy females 47.7% whereas for diabetic males and females improved by 53% and 31.7% and 56.6% and 77.2% for males and females HbA1c 7 - 9 and for HbA1c > 9 respectively. Conclusion: Vitamin D supplementation lowered serum HbA1c values of males and females especially in the group Hba1c values > 9 and this can be considered as a cheap and effective therapeutic tool in the management of type 2 diabetes. Also vitamin D supplementation improved concentration of serum 25(OH) vitamin D in both healthy and diabetic group upgrading their vitamin D status from deficiency to sufficiency.
VITAMIN D: A POTENTIAL HELPER IN THE FIGHT AGAINST DIABETES MELLITUS
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2021
Vitamin D is the most powerful vitamin, which is the only vitamin that synthesized in our body. The most Vitamin D deficiency disease are Ricket, osteomalacia, osteoporosis, etc. Now a day research study has shown that vitamin D deficit concentration may play important role in the development of Diabetes Mellitus. Vitamin D work on insulin functions by stimulating the beta cell activity. It improves the insulin receptors and glucose transport in to the cell. The deficiency amount of vitamin D intake may lead to the type-II diabetes mellitus. Vitamin D deficiency also led to an increase the level of parathyroid hormone (PTH), which is associated with the insulin resistance. The diet with Vitamin D supplementation reducing insulin resistance and preventing type 2 diabetes mellitus. The purpose of this report is to review the effects of vitamin D on diabetes mellitus.
Vitamin D and Diabetes Mellitus: A Review
Vitamin D deficiency and Diabetes are both disorders of high prevalence in the world. Currently, evidences suggest a possible correlation of low levels of vitamin D with the diagnosis of Diabetes Mellitus. Hypovitaminosis D could be associated with insulin resistance and Diabetes Mellitus, which would in part explain mechanisms involved in the pathogenesis of Diabetes. The aim of this work is to discuss the association between Vitamin D and Diabetes, questioning if vitamin D can prevent the settlement of diabetes or slow down its clinical evolution, and improve the pancreatic function, thus providing a better glycaemic control.
Analysis of Vitamin D in Patients with Diabetes Mellitus Type 2
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 y...
Role of vitamin D on blood sugar level in diabetic patients
Innovative Publication, 2016
Background: Vitamin D3 has been linked to everything as cancer, diabetes mellitus heart disease etc. One important function of vitamin D is on the beta cells of pancreas that secretes insulin. In cases of deficiency of vitamin D there is not only a decreased secretion of insulin but also increased insulin resistance as proved by various studies. Studies have also shown that treatment of vitamin D deficiency delays the development of insulin resistance & so diabetes mellitus. Methods: Our objective was to examine the association of serum 25-hydroxyvitamin D levels with type 2 diabetes mellitus & effects of vitamin D on it. Analysis were carried out on 200 patients (120 men & 80 women) aged about 35 or above conducted for 1 year in 2014. Diabetes mellitus was defined as fasting plasma glucose > 126mg% or current use of oral hypoglycaemic agents or insulin. Results: Compared to individuals with a sufficient serum 25(OH)D concentration >75nmol/L, the observed values are divided into 4 groups severe (<25nmol/L), mild (25 to <50 nmol/L), moderate (50 to<75nmol/L) & normal >75nmol/L. The enrolled patients were investigated for blood sugars, vitamin D levels, lipid profiles & HbA1C status at baseline & at the end of 1 year. Conclusion: Correction of vitamin D deficiency postpones the development of insulin resistance & thus diabetes mellitus & also improves glycemic control.
CERN European Organization for Nuclear Research - Zenodo, 2022
Vitamin D deficiency and its effect have attracted a considerable research interest due to its relation to glucose homeostasis, insulin secretion, sensitivity and synthesis. The aim of this study was to evaluate vitamin D levels in patients with type II diabetes mellitus aged between 35-65 years and investigating their relations with glycemic control and obesity. The study included 74 Libyan patients with known history of type II diabetes mellitus (33 males and 41 females). Serum glucose, glycosylated hemoglobin (HbA1c) and vitamin D levels were biochemically estimated in these patients. Further, body mass index (BMI) was calculated for all the diabetic patients (weight in kilogram per height in meter square). The mean level of plasma glucose level was 150.58 ± 63.82 mg/dl (mean ± SD). The mean of HbA1c level was 7.90 ± 8.48% (mean ± SD). The mean level of vitamin D was 22.7 5 ± 14.97 ng/ml. The mean of BMI was 26.55 ± 4.10 Kg per m 2. The findings showed that 58.10% of the cases had vitamin D deficiency (Out of which 24.24% were males and 85.36% were females). This study showed statistical significance differences in glucose, HbA1c, vitamin D and BMI between male and female patients. Moreover, elderly ages for both sexes had adverse effects on vitamin D status. Vitamin D levels have negatively been correlated with levels of glucose, HbA1c and BMI. It is concluded that vitamin D deficiency has an adverse effect on glucose homeostasis in patients with type II diabetes mellitus and this can be a contributor risk factor in complications of type II diabetes mellitus development in Libyan patients.
Journal of Diabetes & Metabolism, 2018
Background: In India the number of people with diabetes is increasing day-by-day. Due to a sole "Asian Indian Phenotype," Indians develop diabetes an era earlier and have an earlier onset of complications. Therefore, it is essential to evaluate more effective treatment strategies at an earlier stage of disease progression. WHO defines Diabetes Mellitus as a metabolic disorder characterized by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and sometimesketonemia. Aim: To assess and study the effect of Vitamin D supplementation on FBS, PPBS and HbA1clevel in diagnosed patients of Type 2 Diabetes Mellitus. Methods: The present study was Prospective, open label, comparative, randomized, parallel group, two arm interventional study. Comparison of two active treatment groups over a period of six months. Total 120 patients of either sex in the age group of 30 to 60 years with Type 2 Diabetes Mellitus, with HbA1c level >7.0% and <8.5%. The effect of with/without Vitamin Dsupplementwith OHA observed on various parameters i.e. FBG, PPBS, HbA1c. Results: In Group C the mean change in FBS from baseline to 6 months was 162.90 to 127.2 (-35.7); on the other hand, in Group Tfrom baseline to 6 months was 157.90 to 94.93 (-62.97). Whereas, PPBS from 213.40 to 176.17 (-37.23) in Group C; in GroupT from 209.70 to 149.03 (-60.67). On the other hand, in Group C, HbA1c 7.80 to 7.22 (-0.58) and in GroupT, 7.76 to 6.70 (-1.06). Group T statistically highly significant than GroupC in improving glycemic indices. Conclusions: In Treatment Group Vitamin D supplement was responsible for improved levels of FBS, PPBS, HbA1c. In summation, it can be said thatwhen vitamin D levels were adequate control ofglycemic indices.The advantages of the study include: significant reductions, good efficacy, minimal rates of adverse reactions, no toxicity, good compliance.
The Diabetes Educator, 2008
Diabetes is a leading cause of cardiovascular disease. Persons with diabetes are at greater risk for early cardiac mortality, and for repeat events if they survive their first cardiac event. Recently, low serum concentrations of vitamin D have been associated with increased risk for cardiac events. Evidence indicates that persons with diabetes have lower serum concentrations of vitamin D. In addition, persons at risk for diabetes or metabolic syndrome have inadequate serum concentrations of vitamin D. This review will assess the evidence relative to the impact of vitamin D in the development of diabetes, metabolic syndrome, and diabetes complications. Studies that address vitamin D and its impact on metabolic outcomes as well as possible mechanisms of action are provided. Finally, the assessment and suggested treatment for vitamin D deficiency is addressed. Effective detection and treatment of inadequate vitamin D concentrations in persons with diabetes or those at risk for diabetes...
Vitamin D and diabetes mellitus: an update 2013
Arquivos Brasileiros de Endocrinologia & Metabologia, 2014
Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH) 2 D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases. Arq Bras Endocrinol Metab. 2014;58(1):1-8 A deficiência de vitamina D e o diabetes melito são enfermidades comuns na população e são altamente prevalentes em todas as raças, idades, regiões geográficas e situação socioeconômica. Estudos epidemiológicos mostram uma associação entre hipovitaminose D com o aumento do risco de doenças crônicas, tais como câncer, doença cardiovascular, diabetes melito do tipo 2 e doenças autoimunes como a esclerose múltipla e o diabetes mellitus do tipo 1. A identificação de receptores da 1,25(OH) 2 D e da expressão da 1 α-hidroxilase nas células betapancreáticas, em células do sistema imunológico e em uma variedade de células do organismo além do tecido ósseo, suporta o papel da vitamina D na patogênese do diabetes tipo 2 e do tipo 1. Esta revisão apresenta e discute o conceito de deficiência de vitamina D, sua prevalência e seu papel na patogênese e no risco de desenvolvimento do diabetes melito e doenças cardiovasculares. Arq Bras Endocrinol Metab. 2014;58(1):1-8 Descritores Vitamina D; diabetes melito; patogênese
Physiology and Pharmacology, 2021
Introduction: The aim of the present study was to evaluate the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes. Methods: This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with type 2 diabetes mellitus (T2DM) referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vitamin D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay. Results: There was no significant difference between case and control groups in terms of age, sex, body mass index and used medications. The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively. The mean fast blood...