Effect of Vitamin D Supplementation on Blood Glucose Homeostasis, BMI and Lipid Profile in Diabetic Patients with Vitamin D Deficiency (original) (raw)

Background: Vitamin D deficiency seems to be frequent and involved in pathogenesis of numerous diseases, including metabolic abnormalities and glucose homeostasis. The aim of study was to investigate the effect of vitamin D supplementation on FBS, glycemic control, lipid profile and BMI in diabetic patients with vitamin D deficiency. Methods: A case control study conducted on diabetic and non-diabetic patients include 50 health and 150 diabetic patients. Diabetic patients have no or vitamin D deficiency and health control as well. Both were thereafter FBS, HbA1c measured first time on supplemented vitamin D either 50, 000 UI orally or 200,000 IU IM. After three months all blood parameters were measured include FBS, HbA1C, lipid profile and BMI. T test was used for determination of statistical significant between groups. Results: Vitamin D supplementation had profound effect and control FBS, HbA1C, lipid profile and BMI P< 0.05 on both Types 1 and types 2 diabetes mellitus. However, such effect has not been found in counterpart healthy control with vitamin D deficiency. The regular weekly dose of 50,000 IU were found more promising values on FBS, HbA1C, lipid profile and BMI P< 0.05 than the monthly does. Physical activities of cases and control did not shown to have any cofound factors on FBS, HbA1C, lipid profile and BMI. Conclusion: Vitamin D can be considered as a therapeutic agent along with the other treatments for both types of Diabetes mellitus in which could be deemed to use for routine treatment due to vitamin D deficiency is worldwide problem.