Burkitt Lymphoma with Multiorgan Involvement (original) (raw)
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Burkitt's Lymphoma: Clinicopathologic Features and Differential Diagnosis
The Oncologist, 2006
Learning Objectives After completing this course, the reader will be able to: Describe the events leading to the initial identification and description of Burkitt's lymphoma and the discovery of its association with the Epstein-Barr virus.Outline the WHO Classification of Burkitt's lymphoma, including the clinical and pathological variants of this lymphoma.Discuss the treatment strategies used for treating Burkitt's lymphoma.List the criteria for establishing a diagnosis of Burkitt's lymphoma and discuss the entities that may enter its differential diagnosis. Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. Since its description in African children, it has been recognized outside areas with endemic malaria, frequently also in children as well as among individua...
British Journal of Cancer, 1986
An eight year old English boy presented with an abdominal undifferentiated 'Burkitt-like' lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (a1). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African 'endemic' Burkitt's lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was indistinguishable from that previously shown by biopsies of EBNA positive endemic BLs. It therefore appears that both the endemic and sporadic forms of BL, as illustrated by this case, may be derived from the same subset of progenitor cells.
Burkitt Lymphoma in Children: An Unusual Presentation
Frontiers in Medical Case Reports, 2020
Burkitt lymphoma is an extremely aggressive and fast-growing mature B-cell non-Hodgkin lymphoma. There are three clinical variants of Burkitt's lymphoma: endemic or African, sporadic and related to immunodeficiency. The sporadic variant of Burkitt's lymphoma is mainly present in Western countries and represents 40% of all childhood non-Hodgkin lymphomas. The average age of onset is 8 years. In pediatric age, sporadic Burkitt lymphoma is mainly an extranodal disease and at diagnosis the most commonly involved site is the gastrointestinal system, in the form of a massive abdominal mass occupying the lower right quadrant and which arises in the region of the ileocecal valve. Sporadic Burkitt lymphoma occurs less frequently with cervical lymphadenopathies, and other organs such as the brain, lung, liver, spleen, kidney and bone are commonly affected in the systemic spread of the tumor. In this article we describe an unusual presentation of advanced LB. A 5-year-old boy came to our observation due to a left submandibular lymph node swelling that was biopsied with the diagnosis of LB. Subsequently, radiological investigations performed for staging unexpectedly showed liver, kidney and brain injuries.
Burkitt Lymphoma: A Case Report
Journal of Pharmaceutical Research International
Introduction: Burkitt lymphoma is highly metastatic active malignant B- cell Non-Hodgkin’s Lymphoma characterized by translocation and deregulation of the d- MYC gene on chromosome no.8 on DNA strand. Background: Burkitt lymphoma (BL) accounts for 30–50% of all peadiatric lymphomas, and non-Hodgkin lymphoma (NHL) is the fourth most common malignant tumor in children. In the sex distribution, there was a male predominance, especially among children Case Presentation: A 12 year old female child was brought to Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, Maharashtra, India on date 12/01/2020 with complaints of breathlessness since 5 days, high grade fever since 10 days and retrosternal chest pain since 10- 15 days along with anorexia. The patient had a complete blood count, which revealed that his hemoglobin percent, total red blood count, hematocrit and Mean Corpuscular Hemoglobin were all low. Pleural Fluid cytology analysis, Virology investigation, CECT Chest and C...
Oral Oncology, 1998
This article presents a review of the epidemiology of Burkitt's lymphoma, its correlation with Epstein±Barr virus and AIDS, its clinical features and incidence, and the prevailing environmental and socioeconomic conditions which are related to it.
Burkitt Lymphoma: beyond discoveries
Infectious Agents and Cancer, 2013
First described in 1958 in Uganda, Burkitt lymphoma (BL) attracted interest worldwide following reports of its uneven geographic distribution and rapidly fatal clinical course. Both suggested infectious etiology and curability. Seminal discoveries followed in quick succession. Viral etiologydue to Epstein-Barr virus (EBV)was confirmed. Chromosomal translocations, involving cellular MYC, a protooncogene, were discovered, shown to be a hallmark of BL, and central to the genetic basis of cancer. Cure of BL using combination chemotherapy was demonstrated. Unfortunately, civil disturbance in Africa disrupted BL research and blunted its impact on education and oncology care in Africa. Important questions went unanswered. The risk of BL due to malaria or EBV was not quantified. Efforts to answer whether BL could be preventedby preventing malaria or early EBV infectionwere abandoned. The mechanism of malaria in BL is unknown. In Africa, BL remains mostly fatal and diagnosis is still made clinically. Unprecedented advances in molecular, genomics and proteomic technologies, promising to unlock mysteries of cancers, have re-awakened interest in BL. With return of stability to Africa, the unanswered questions about BL are re-attracting global interest. This interest now includes exploiting the knowledge gained about genetics, proteomics, and bioinformatics to enable the development of targeted less toxic treatment for BL; and simpler methods to diagnose BL with high accuracy and sensitivity. The articles in the Burkitt Lymphoma (BL): Beyond Discoveries in Infectious Agents and Cancer highlight BL as priority. Authors explore etiology, pathology, pathogenesis of BL, and whether knowledge gained in the studies of BL can catalyze sustainable cancer services in one of the world's poorest served regions.
African Burkitt's lymphoma: a new perspective
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2001
High titres of antibody to Epstein-Barr virus (EBV) late genes identify individuals at risk of developing endemic Burkitt's lymphoma (eBL). Vial lytic cycle early and intermediate-early gene expression in BL is associated with a favourable tumour response to chemotherapy. Our study investigated whether serological data identifying antibody expression to zta, a viral function that activates lytic-cycle gene expression, correlate with expression of its gene in turnours, and couid have prognostic value. Studies on 10 Malawian patients, with presumed BL on clinical grounds, showed good correlations, suggesting that serum antibody responses might predict treatment responsiveness. The results with 1 patient were particularly striking. When admitted in January 1998, prognosis was poor as he was unable to walk, and had tumour cells, characteristic of stage IV disease, in his bone marrow. Laboratory investigations showed particularly high levels both of serum ZEN antibodies and of gene expression in his tumour. Follow-up confirmed him alive 6 months after hospital discharge. Among the EBV-positive cases, 2 were ultimately diagnosed as rhabdomyosatcoma, a tumour not previously associated with this virus. The findings from this small study, if confirmed, should have value for future BL management in resource-poor parts of the world.
IP innovative publication pvt ltd, 2020
Introduction: Burkitt lymphoma is an aggressive type B-cell NHL. It is an infrequently occurring aggressive B-cell NHL, which occurs in children and young adults and it is probably the fastest growing tumor in humans, with exuberant proliferation. However, it is now one of the most curable conditions in the developed world. Objective: The aim of this study to analyze the clinico-pathologic, immunophenotypic, cytogenetic and molecular pathology of cases diagnosed as Burkitt lymphoma/leukemia. Materials and Methods: All cases diagnosed as Burkitt lymphoma/leukemia (BL) between2008 and 2016 were included in this study. All the relevant data was collected from Pathology and Oncology records. Peripheral blood, bone marrow smears and histopathology slides were reviewed. Stains like Giemsa, Oil -Red-O and Hematoxylin and Eosin (H&E) were reviewed. Immunohistochemistry with lymphoma markers were done on tissue sections. Immunophenotyping on marrow aspirates was done with 4-color flowcytometry. Flourescence In-situ Hybridization (FISH) assay was performed on some bone marrow aspirate samples. Results: During this study period, 37 cases were diagnosed as Burkitt leukemia / Lymphoma. There were25 male and 12 female (M: F: 2.2:1). Ten patients had hepatosplenomegaly and 8 had lymphadenopathy. B-type symptoms in 21 patients and raised LDH levels in 17 cases were observed. There were 25 patients diagnosed on bone marrow studies (21 fresh cases and 4 cases of relapse). Twelve patients were diagnosed as high grade NHL on histopathological examination (HPE). Flow analysis was done in 6 cases, which were positive for CD10, CD19, and CD20. Immuno histochemistry on biopsy specimens was done in 12 cases and 3 trephine biopsy sections were positive for B-cell lymphoma markers with high Ki67. FISH analysis was performed on 5 specimens and showed c -MYC rearrangement and t (8-14) translocation Conclusion: Burkitt lymphoma/leukemia is an aggressive variant of B cell NHL. It has classical morphology with monomorphic large lymphoid cells with prominent punched out vacuoles, positive for lipid vacuoles. Even with aggressive chemotherapy, seven cases were in remission and majority patients expired. As per our knowledge this is the largest case series from India.
Burkitt's lymphoma in Africa, a review of the epidemiology and etiology
African health sciences, 2007
Burkitt's lymphoma (BL) was first described in Eastern Africa, initially thought to be a sarcoma of the jaw. Shortly it became well known that this was a distinct form of Non Hodgkin's lymphoma. The disease has given insight in all aspects of cancer research and care. Its peculiar epidemiology has led to the discovery of Epstein Barr virus (EBV) and its importance in the cause of several viral illnesses and malignancies. The highest incidence and mortality rates of BL are seen in Eastern Africa. BL affects mainly children, and boys are more susceptible than girls. Evidence for a causal relationship between EBV and BL in the endemic form is fairly strong. Frequency of association between EBV and BL varies between different patient groups and different parts of the world. EBV may play a role in the pathogenesis of BL by deregulation of the oncogene c-MYC by chromosomal translocation. Although several studies suggest an association between malaria and BL, there has never been a...