MICROENCAPSULATION TECHNIQUES, FACTORS INFLUENCING ENCAPSULATION EFFICIENCY (original) (raw)
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Microencapsulation techniques, factors influencing encapsulation efficiency: a review
The Internet Journal of …, 2009
Microencapsulation is one of the quality preservation techniques of sensitive substances and a method for production of materials with new valuable properties. Microencapsulation is a process of enclosing micron-sized particles in a polymeric shell. There are different techniques available for the encapsulation of drug entities. The encapsulation efficiency of the microparticle or microsphere or microcapsule depends upon different factors like concentration of the polymer, solubility of polymer in solvent, rate of solvent removal, solubility of organic solvent in water, etc. The present article provides a literature review of different microencapsulation techniques and different factors influencing the encapsulation efficiency of the microencapsulation technique.
2013
Microencapsulated dosage forms represent effective new therapeutic platforms. This special issue will cover the different interests of microencapsulation as a mean s to control or modify the release of drug substanc es from drug delivery systems. To overcome the drug stability pr oblem, since clinical efficacies have been reported to be improved by the encapsulation of pharmaceuticals, the bioava lability of drugs, control drug release kinetics, minimizing drug side effects, and taste masking of the drug substan ces. Microencapsulation is process of enclosing mic ro sized particles in a polymeric shell. There are different technique s available for the encapsulation of drug entities. Most of the applied techniques of micro-encapsulation are based on modi fications of the four basic methods: spray-drying, phase separation (coacervation), gelation and solvent extraction/eva por tion. The encapsulation efficiency of the micro particle or microsphere or microcapsule depends upon differe...
Microencapsulation Technology a Holistic Approach in the Field of Pharmaceutical Sciences a Review
International Journal of Pharmaceutical Sciences Review and Research
Microencapsulation is a technique that uses a coating to encapsulate microscopic particles or droplets in order to generate miniature capsules with therapeutic properties. The substance contained within the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is referred to as a shell, coating, or membrane. A microcapsule is a small object that contains essential items, internal components, or fillers and is encased by a shell, cover, or membrane. Microcapsules range in size from 1 to 1000 micrometres. This approach is frequently used for medication administration, molecular protection, and robustness. The microencapsulation programme has been established as a different delivery mechanism for multiple treatment regimens and offers potential benefits beyond those of normal medication delivery systems. Microencapsulation is a well-established review dedicated to the preparation, properties, and applications of individually encapsulated novel small particl...
It is a comparative study of salbutamol sulpahte-ethylcellulose microcapsules prepared by three different microencapsulation techniques i.e. coacervation thermal change, solvent evaporation and coacervation nonsolvent addition by adjusting the ratio of salbutamol sulpahte to ethylcellulose. In vitro release profiles of microcapsules were studied using USP XXIV dissolution apparatus-I in 450 ml double distilled water maintained at 37°C at 50 rpm. Scanning electron microscopic results indicated that all microcapsules were aggregated, whitish and irregular in shape with good entrapment efficiency (86.34 to 97.83), production yield (87.91±1.34 to 98.33±1.37) and flow properties. Initial burst effect was observed in the drug release behavior from all microcapsules. A slight increase in actual drug loading but profound increase in mean diameter of microcapsules was observed with the increase in the viscosity of ethylcellulose. UV and FTIR spectroscopy, x-ray diffractometry and thermal analysis verified the absence of any strong chemical interaction between drugs and polymer. The drug release from all the formulations followed anomalous diffusion mechanism and was best fit to Higuchi's kinetic model. The results suggest coacervation thermal change as an appropriate approach to develop slow-release multi-unit oral dosage form of salbutamol sulpahte suggesting at least twice administration in every 24 hours.
International Journal of Pharma and Bio Sciences MICROENCAPSULATION: A REVIEW
Microencapsulation is the process of surrounding or enveloping one substance within another substance on a very small scale, yielding capsules ranging from less than one micron to several hundred microns in size. The encapsulation efficiency of the microparticles or microsphere or microcapsule depends upon different factors like concentration of the polymer, solubility of polymer in solvent, rate of solvent removal, solubility of organic solvent in water etc. Microencapsulation may be achieved by a myriad of techniques. Substances may be microencapsulated with the intention that the core material be confined within capsule walls for a specific period of time. Alternatively, core materials may be encapsulated so that the core material will be released either gradually through the capsule walls, known as controlled release or diffusion, or when external conditions trigger the capsule walls to rupture, melt, or dissolve. This article is a review of microencapsulation and materials involved in it, morphology of microcapsules, microencapsulation technologies, purposes of microencapsulation, and benefits of microencapsulation, release mechanisms, and application fields, with special emphasis on microencapsulated additives in building construction materials.
Microencapsulation technique by solvent evaporation method (Study of effect of process variables
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES , 2011
The preparation of microsphere by solvent evaporation method has been studied extensively to prepare a microsphere using biodegradable polymer. The properties of biodegradable microsphere of poly (lactic acid) (PLA) and (acid lactic-co-glycolic) (PLGA) have been extensively investigated. The encapsulation of highly water soluble compounds including proteins and peptides is providing challenges to the pharmaceutics person. The successful encapsulation of such entities requires high drug loading in the microsphere, prevention of protein degradation by the encapsulation method, and predictable release of the drug compound from the microsphere. Multiple emulsion techniques and some other innovative modifications have been made to the conventional solvent evaporation process. A several process variable affecting the quality of product has been studies in this review.
Microencapsulation Technology For Novel Pharmaceutical Formulations
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES, 2024
Microencapsulation is essentially a method or process that forms microcapsules by applying thin coatings to dispersions, small solid particles, or liquid droplets in a repeatable manner. Its particle size ranges from several tenths of a micron to 5000?, which makes it easily distinguishable from other coating techniques. The microencapsulation process offers solutions for a number of issues, including how to make prolonged-action dosage forms, mask the taste of bitter medications, separate incompatible materials, shield chemicals from oxidation or moisture, and change a material's physical properties to make them easier to handle during formulation and manufacturing. Compared to traditional multiple dose therapy, novel drug delivery systems offer a number of benefits. Currently, significant efforts are being made to administer the medication in a way that will get maximum advantages. Pharmaceutical dosage forms with delayed drug release can be altered by using microencapsulation.
Significance of Microencapsulation Technology: A review
Journal Advances of Nutrition Science and Technology, 2022
Microencapsulation is an emerging technology that involves the formation of microcapsules by entrapping active agents inside coating or wall material; all these ingredients must be biodegradable. Different technologies are being adopted for better microencapsulation of food ingredients and novel drug delivery. Selection of microencapsulation technology, coating/wall material & core material in relevance with each other can play a significant role in getting potentially promising results. The main reason for using microencapsulation technology is to protect sensitive components of food, prevent nutritional losses, ensure the utilization of sensitive ingredients, mask the unpleasant smell, and convert liquid into solid ingredients that can be handled easily. Drugs are released at their targeted sites in the gastrointestinal tract due to different mechanisms like Diffusion, osmosis, dissolution & erosion. This review paper aims to provide reasons, applications of microencapsulation, core & coating material, some effective technologies used for microencapsulation, and recent literature on these aspects.
A Review On MICROENCAPSULATION TECCHNIQUE
2020
Microencapsulation can be described as heavy, fluid or gaseous substance packaging engineering with thin polymeric coatings, creating small particles called microcapsules. Microencapsulation is very helpful to increase the solubility of drugs. For the drugs of BCS Class-II we use this techniques which enables us to get more solubility and increase dissolution profile. This is the novel method of drug delivery. In future aspect we can use this technique in food industry, beverages. Microencapsulation approach for the preparation of an intrauterine contraception system was also suggested. This technique is helpful to overcome poor solubility, low Bioavaibility and less stability. This method also give more control over the drawback of conventional dosages form.