Melatonin reduces mortality and oxidatively mediated hepatic and renal damage due to diquat treatment (original) (raw)

Melatonin has been shown to mitigate the harmful effects of diquat, a widely used herbicide that generates reactive oxygen species leading to severe oxidative damage in the liver and kidneys. In experiments with Kunming mice, treatment with melatonin significantly reduced both hepatic and renal toxicity, as indicated by lower levels of alanine aminotransferase, blood urea nitrogen, and F2-isoprostanes—biomarkers of oxidative stress. These findings suggest that melatonin may be a beneficial therapeutic agent against oxidative damage caused by diquat.