Xanthomatous oophoritis, a rare pathology: case report with review of literature (original) (raw)
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Xanthogranulomatous inflammation: a rare cause of premature ovarian failure
Archives of Gynecology and Obstetrics, 2009
Xanthogranulomatous inXammation is rare, mainly involving the kidneys, histologically characterized by partial or complete replacement of the mucosa by granulation tissue with an abundance of foamy histiocytes, siderophages and multinucleated giant cells. We report an unusual presentation of xanthogranulomatous inXammation of the genital tract in a young female presenting with premature ovarian failure. A 25-year-old unmarried female presented to the gynecology OPD with amenorrhea and lump abdomen for one and half years with weight loss and mucoid discharge per rectum for 2 months. On investigating, CECT showed a heterogeneously enhancing mass lesion with solid cystic components in pelvis. Cystic components showed enhancing walls and air Xuid levels. Uterus and ovaries were not seen separately. There were multiple lymph nodes in retroperitoneum. Both LH and FSH were raised to post menopausal levels (FSH-69.35, LH-64.53). A provisional diagnosis of ovarian malignancy was made and a diVerential diagnosis of genital tuberculosis was kept and a decision for laparotomy was taken. Intraoperatively, there was a mass arising from the right side of fundus stuck to rectum. There was a pus pocket in the tumor. The Wnal histopathological report was suggestive of endometrioma with xanthogranulomatous inXammation involving adjacent ovary and fallopian tube.
Xanthogranulomatous Oophoritis- A Rare Inflammatory Lesion
Xanthogranulomatous inflammation is a special form of chronic inflammation that is destructive of affected organ. Xanthogranulomatous inflammation of ovary and fallopian tube is an uncommon entity and it is usually known to occur in the kidney and gall bladder. Patients with xanthogranulomatous oophoritis present with lower abdominal or suprapubic pain, fever, menorrhagia or vaginal bleeding, adnexal tenderness and a pelvic mass. This entity can be confused with ovarian tumour on clinical and radiological features. According to our search in the literature 16 cases of xanthogranulomatous oophoritis have been reported. We report a 30 year old female, presented with a unilateral ovarian mass with clinical and radiological suspicion of ovarian tumour. Patient underwent panhysterectomy, grossly the right ovary was enlarged and on cut section it was solid with yellowish areas. Histopathological examination revealed massive infiltration of the ovarian tissue and fallopian tube by lipidlad...
2021
Xanthogranulomatous oophoritis is an uncommon chronic inflammatory process in which native ovarian tissue is destroyed and replaced by marked infiltration by foamy histiocytes, accompanied by other inflammatory cells with or without foci of necrosis or fibrosis. The exact aetiology remains unclear but it has been linked to chronic pelvic inflammatory disease (PID) and Tuberculosis which are endemic in sub-Saharan Africa, including Nigeria. We report a case from a 25 year old female who presented with recurrent lower abdominal pain and an adnexal mass.
Surprisingly benign histopathology in a case of malignant looking ovary
The New Indian Journal of OBGYN
Xanthogranuloma is a non-neoplastic presentation of chronic inflammation commonly seen in gallbladder, kidneys and rarely seen in genital organs. Herein, we report a case of xanthogranulomatous oophoritis in a 45 year female who presented with lower abdominal pain and backache. There was an ill defined mass around 14 weeks size of gravid uterus. USG and CECT scan of abdomen confirmed it to be enlarged multiloculated right ovary 7.2×6.5×6.5 cms with multiple enhancing thick septations. CA125, CA19-9 and LDH were raised. The mass was clinically and radiologically misdiagnosed as ovarian neoplasm. Staging laparatomy was done. Histopathological findings revealed characteristics features of xanthograulomatous oophoritis. Xanthogranulomatous oophoritis should be kept in mind while dealing with cases of ovarian tumors to prevent misdiagnosis of malignancy and to avoid radical surgeries.
https://www.ijhsr.org/IJHSR\_Vol.6\_Issue.3\_March2016/48.pdf, 2016
Xanthogranulomatous salpingo-oophoritis is a rare form of chronic granulomatous inflammation with many etiologic factors implicated in the pathogenesis. On radiology its presents as well defined solid mass mimicking malignancy. Grossly the mass shows yellowish necrotic material and on microscopy the affected organ has disorganization and infiltration with focal or sheets of foam cells admixed with chronic inflammatory cells such as lymphocytes, plasma cells, occasional neutrophils with or without multinucleated or Touton giant cells. The awareness of this inflammatory lesion among clinicians and the pathologists can prevent misdiagnosis and radical surgery.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Xanthogranulomatous inflammation is a rare type of chronic inflammation. It destroys the tissue of the affected organ, mostly affecting the kidney and gall bladder. Xanthogranulomatous inflammation of female genital tract being a rare entity, only few numbered cases involving the ovary have been reported in literature. This chronic inflammation of fallopian tubes and ovaries, usually present with pelvic masses, and on imaging and macroscopic appearance, are mostly misdiagnosed as ovarian neoplasm or tuberculosis. We are presenting a case of 14-year-old girl, who presented with an abdominal lump and on clinical and radiological investigations was suspected as ovarian malignancy but histo-pathology reported it as serous cystadenoma with xanthogranulomaotus oophoritis. The rarity of this case lies in the fact that rare destructive inflammatory features was present in a benign neoplasm of the ovary (serous cystadenoma) and that too in a youngest age reported till now.
Journal of Case Reports and Scientific Images, 2020
Xanthogranulomatous inflammation of ovary is a non-neoplastic, rare chronic process in which the ovary is damaged by massive cellular infiltration of foamy histiocytes admixed with plasma cells, fibroblasts, multinucleated giant cells, neutrophils, and necrotic foci. The etiology remains unknown, but it does share the histopathological findings of xanthogranulomatous change occurring in different organs, including the gallbladder and kidney. The current case was a 24 year old female presenting with an ovarian mass with high suspicion of malignancy on clinicoradiological evaluation. A vigilant histopathological study was carried out and the final diagnosis of xanthogranulomatous oophoritis was established.
Xanthogranulomatous salpingo-oophoritis mimicking an ovarian malignancy: a clinical dilemma
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Xanthogranulomatoussalpingo-oophoritis is an uncommon form of chronic inflammation in the genitourinary tract. Its symptoms and radiological findings mimic ovarian malignancy. Aim of this study was to evaluate the clinicopathological pattern of xanthogranulomatous salphingo oophoritis.Methods: This study was conducted in the department of pathology, Government Medical College, Srinagar. It was a retrospective study done over a period of 5 years, November 2014 to November 2019.Results: The study was done to evaluate the clinicopathological pattern of 6 cases of rare entity xantogranulomatous salphingo oophoritis diagnosed at a tertiary care hospital. All patients, presented with pain abdomen. All patients were operated due to radiological suspicion of ovarian malignancy. Histopathological examination proved the lesion as xanthogranulomatous salphingo oophoritis.Conclusions: Xanthogranulomatoussalpingo-oophoritis is a rare condition that is often mistaken for ovarian malig...
A rare case of xanthogranulomatous oophoritis
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Xantho-granulomatous oophoritis is an uncommon, non-neoplastic, chronic process affecting female genital tract. Its clinical and radiological features mimic ovarian neoplasm. Here we present a case report of 42-year-old female with chronic pelvic pain with adnexal mass with infertility and raised CA 125 levels. Histopathological examination revealed it to be a case of xantho-granuous oophoritis. Xantho-granulomatous oophoritis is very rare disease and only few cases have been reported so far and this case is being reported in view of its rarity.
Journal of Obstetrics and Gynaecology Research, 2012
Xanthogranulomatous inflammation is a rare form of chronic granulomatous inflammation. Bacterial infections, immunosuppression, chronic inflammatory conditions, luminal obstruction, endometriosis, leiomyoma, abnormal lipid metabolism, ineffective antibiotic therapy, ineffective clearance of bacteria by phagocytes and chronic irritation of the urachal remnant have been implicated in the pathogenesis. There are very few reported cases of xanthogranulomatous salpingitis and oophoritis. We present such a case in a 34‐year‐old female, with primary subfertility for eight years, endometriosis, uterine leiomyoma, type II diabetes mellitus and a history of surgery for endometriosis and fibroids and surgical wound infection, who presented with symptoms of intestinal obstruction. The patient underwent emergency laparotomy followed by total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Histology revealed xanthogranulomatous salpingitis and oophoritis. Chronic inflammation due to i...