Absolute configuration of amino alcohols by 1H-NMR (original) (raw)

The assignment of absolute configuration of amino alcohols through 1H-NMR has witnessed significant advancements, particularly in the development of chiral derivatizing agents and innovative methodologies. Previous techniques faced challenges when applied to complex polyfunctionalized molecules, necessitating more intricate protocols for accurate stereochemical determinations. This research presents a systematic study of syn and anti diols, demonstrating effective configurational assignments through bis-AMAA derivatives, establishing a reliable method for discerning the stereochemistry of compounds with multiple chiral centers.