Effect of RPR-V, a thiol Derivative of monocrotophos on housefly acetylcholinesterase. Journal of Ecotoxicology and Environmental Monitoring 8, 29–36 (1998) (original) (raw)

Insc£ticidal studies of monocrotophos (MCP) and its newly synthesized thiol analogue RPR-V were: died on housefly MIl!JCQ domestica Linnaeus (Diptera:Muscidae). RPR-V exhibited high insecticidal acitivity with LD 50 ofO.0747Jlglinsect when compared to MCP, which is leis active with LD 50 0fO.093J.lg1 insect. The study on inhibition of housefly head acctylcholincscsterasc (AChE) activity indicated in vitro neurotoxic potentialitity of these two organophosphorus pesticides. MCP and RPR-V have shown competitive inhibition on AChE and altered the K,. values widely in a dose dependent manner.~on the K 1 values, RPR-V wns found to be more active than MCP.