Temperature Stability And Antibacterial Activity Of Cefepime (CFP) During Continuous Infusion (CI) Administration (original) (raw)

Abstract

Background: Time above MIC (T>MIC) is the pharmacodynamic parameter that best correlates with bacterial killing for CFP. CFP via CI achieves T>MIC throughout the dosing interval. The purpose of this study is to determine whether CFP exhibits sufficient stability and antibacterial (ABX) activity to be given by 24-hour CI using portable infusion pumps (PIP). Methods: The stability of CFP in D5W solns. was determined in ten replicates for a simulated CI using a PIP (Microject 30, Sorensen Medical) worn over a period of 24-36 hours. The temp. in the bags were measured every ½ hr using a device placed adjacent to the drug-reservoir. CFP concs. were measured by HPLC. Mass spectrometry (MS) was used to identify the major degradation products by comparing mass ions signatures of fresh with degraded solns. The ABX activity of the CFP solns. were measured by comparing the MICs and MBCs of fresh and degraded solns against a reference strain of P. aeruginosa according to NCCLS. The degrad...

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