The Effect of Doxycycline on Sputum Biomarkers of Inflammation and Airway Remodeling in Patients with Cystic Fibrosis (original) (raw)

Abstract

Purpose: Chronic Pseudomonas aeruginosa infection causes an inflammatory response in the airways of CF patients. Accumulation of neutrophils and release of proteolytic enzymes (i.e. matrix metalloproteinase-9) causes airway destruction. We determined the effect of doxycycline on airway inflammation by measuring proteolytic enzyme levels (i.e. MMP-9) in induced sputum, correlated level changes with patient pulmonary function, and evaluated safety with short-term administration. Methods: A prospective, open-label, randomized controlled study was conducted to determine effects of doxycycline on inflammatory biomarkers. Eight of 24 patients have been stratified according to pulmonary function: mild (FEV1>70%) or moderate (FEV1 40-70%) and randomized in block to receive no drug, 40 mg, 100 mg, or 200 mg for 28 days. The first dose was administered intravenously. All subsequent doses were given orally. Induced sputum and spirometry were obtained during the 28-day treatment period and a...

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