PET/CT positive in a case with eosinophilic granuloma (original) (raw)

Radio-Cytopathological Diagnosis of Eosinophilic Granuloma of Skull in a 13-Year Old Boy

Eosinophilic granuloma is benign end of the spectrum of the Langerhans cell histiocytosis (LCH) which is characterized by solitary or multiple lesions in bones, skin, lung, lymph node etc. Here, we present a case of a 13-year old boy with pain and swelling in the right parietal region of skull with no other complaint. A computerized tomography (CT) scan and subsequent fine needle aspiration cytology (FNAC) revealed solitary eosinophilic granuloma which was subsequently confirmed by histopathology. Minimally invasive procedures like imaging and FNAC usually suffice for diagnosing and following up of patients with this rare disease.

False Positive F-18 FDG PET/CT of Skeletal Metastasis Due to Solitary Eosinophilic Granuloma

Malecular Imaging and Radionuclide Therapy, 2013

Fokal sağ orta-posterior göğüs ağrısı ve kemik sintigrafisinde (SPECT/CT) sağ 7. Kosta posteriorunda soliter litik lezyonu olan 31 yaşında kadın hasta, malignite şüphesiyle alternatif biyopsi bölgesi tanımlanması amacıyla PET/CT için refere edildi. Hastanın tıbbi geçmişinde önemli bir bulgu yoktu ve hafif artmış enflamatuar markerların yanı sıra ateşi yoktu. Sağ 7. kostanın posteriorunda, kısmi kortikal erozyon gösteren belirgin litik lezyona lokalize yoğun soliter FDG tutulumu görüldü. 7 kaburga. Hiçbir komşu yumuşak doku anormalliği görülmedi. Biyopsi için başka hiçbir bölge tanımlanamadı. Malignite (metastatik veya primer) ekarte edilmediği içinhookwire ile CT rehberliğinde lokalizasyon ve mavi boya enjeksiyonu sonrasında sağ 7. kostanın kısmi rezeksiyonu yapıldı. Histopatoloji, Eozinofilik Granülom tanısını doğrulandı.

Spontaneous Regression of Eosinophilic Granuloma

Abstract : Background: Langerhans Cell Histiocytosis (LCH) is a rare neoplasm characterized by abnormal proliferation of histiocytic cells. Primary tumorous lesions of the clavicle are very rare entity, and little literature is available regarding their characteristics and outcome. Though rarely reported, neoplasms of the clavicle occur, and their symptoms can be mistaken for more common shoulder conditions. We here present a case of Benign neoplasm of clavicle in a 4 year old child, presenting with complain of pain and swelling at the lateral end of clavicle. Patients Radiograph and MRI was done. Patients USG Guided FNA that was examined cytologically and was suggestive of Eosinophilic Granuloma. Patient was managed conservatively. At regular follow – up it was observed that the lesion reduced and the patient had a pain free lateral end of clavicle at the end of 2 years. Through work – up for common shoulder conditions often identifies incidental benign lesions of bone, the converse can be true. Persistent pain despite intervention should raise concern for further investigation. An x-ray alone can reveal a destructive bone lesion as the source of shoulder pain. Keywords : Eosinophilic Granuloma

Eosinophilic granuloma of skull in a 7 year child: Diagnosed on fine needle aspiration cytology

Cumhuriyet Medical Journal, 2013

Eosinophilic granuloma is a rare bone tumor, representing less than 1% of all bone tumors. Eosinophilic granuloma is the benign form of three clinical variants of Langerhans cell histiocytosis (LCH). It commonly affects children and young adults, particularly males. The characteristic cytologic features of eosinophilic granuloma include langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils and lymphocytes. We are reporting a case of eosinophilic granuloma of skull in a 7 years child diagnosed on fine needle aspiration cytology (FNAC). We here by emphasize the importance of rapid and reliable diagnosis of LCH by FNAC and the need to consider the possibility of LCH in the differential diagnosis of a slide showing a large number of histiocytes and eosinophils.

Plasmacytoma of the Rib in Young Male

Asian Cardiovascular and Thoracic Annals, 2002

Solitary plasmacytoma of the 11th rib with soft tissue extension was seen in a 29year-old male. Hematological and biochemical profiles did not reveal any systemic involvement. The 12-cm fusiform expansile lesion was excised and subjected to histopathological examination. The sections revealed sheets of plasma cells with focal cortical discontinuity and adjacent soft tissue invasion. This case is unique in view of the age of occurrence and the site of the lesion.

Solitary eosinophilic granuloma of the parietal bone in an adult patient

Neurosciences (Riyadh, Saudi Arabia), 2007

Eosinophilic granuloma (EG) is a well-recognized benign form of Langerhans-cell histiocytosis. The estimated incidence of EG is 3-4 per million of the population. More patients are children and adolescents between the ages of 1-15 years. In this report, we present an adult patient. A 37-year-old male was admitted with headache and right parietal swelling that was present for 2 months together with epileptic attacks. Cranial CT scan revealed a right parietal osteolytic lesion with large epidural and subcutaneous mass, causing brain compression. Total removal of the mass was carried out with cranioplasty. Histopathological examination disclosed Langerhans cell histiocytosis and immunohistochemical detection of S-100 antigen. At follow-up, he had no neurological deficits, and control CT was normal. For symptomatic solitary calvarial EG, surgical excision is the main treatment option. Surgical treatment is simple, quick, and allows histological diagnosis of the osteolytic lesions.