Metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla (original) (raw)

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005

Abstract

In vivo<sup>1</sup>H short echo-time Magnetic Resonance spectra are made up of overlapping spectral components from many metabolites. Typically, they exibit low signal-to-noise ratio. Metabolite concentrations are obtained by quantitating such spectra. Quantitation is difficult due to the superposition of metabolite resonances, macromolecules, lipids and water residue contributions. A fitting algorithm invoking extensive prior knowledge is needed. We quantitated<sup>1</sup>H in vivo mouse brain spectra obtained at 7 Tesla using the time-domain QUEST method combined with in vitro metabolite basis set signals. Brain metabolite concentrations estimated from eight mouse brain signals are compared to previously reported results.

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