Stroke in Asia: geographical variations and temporal trends (original) (raw)

Abstract

Asian countries are in various stages of epidemiological transition and therefore exhibit a great diversity in disease patterns. Collectively, they comprise almost two-third of the world's total mortality due to stroke. The purpose of this review is to explore existing epidemiological data on stroke, highlight the temporal trends in stroke epidemiology in various regions of Asia and predict future patterns based on these observations. Our search revealed that there is a lack of good epidemiological data from most Asian countries. Whatever data exist are not comparable due to lack of standardised methodology for ascertaining stroke and its subtypes. For this and other reasons, these estimates exhibit country-to-country variation and also withincountry variability. We have also reviewed temporal trends in stroke incidence and prevalence in 12 Asian countries and the evolution of stroke subtypes over the past two decades. Important observations include a rise in stroke incidence in most Asian countries, an earlier age at onset compared with the West, a relative increase in the proportion of ischaemic strokes and a decline in haemorrhagic strokes. Among ischaemic stroke subtypes, lacunar strokes, which were once the commonest variety, are now declining. Emerging data suggest that large artery atherosclerosis and in particular that of intracranial vessels is the predominant aetiology in most Asian countries. The review also identified important gender differences in terms of stroke risk factors, prevalence and outcomes. There is need for sound epidemiological data from most countries to understand the disease better and plan policy-level interventions to decrease the burden. We identify a need for standard format or guidelines for conducting stroke epidemiological studies especially in developing Asian countries. This region must be identified as a priority region for stroke-related interventions and preventive strategies by global healthcare authorities and organisations.

FAQs

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What patterns exist in stroke incidence across various Asian countries?add

The study reports incidence rates ranging from 116 to 219 per 100,000 per year in China, Japan, Korea, India, and Singapore, highlighting considerable variability. For example, Pakistan's rates are less reliable as they are based on physician surveys rather than robust population-based studies.

How do regional stroke subtypes vary within Asia?add

In China, Taiwan, and Pakistan, small vessel disease predominates, while Japan and Korea report more large vessel disease cases. Additionally, high rates of cardioembolic strokes are observed in Israel, Iran, and Japan, indicating a complex landscape of stroke subtypes.

What changes in stroke epidemiology have been observed in Japan?add

Japan has seen a significant decline in stroke mortality since the 1950s, though it remains a leading cause of death. Recent data indicate a decrease in both ischemic and hemorrhagic stroke incidences, although the decline has slowed since the 1970s.

What challenges exist regarding stroke epidemiological data in Asia?add

The review reveals a lack of robust data and standardized methodologies, making it difficult to compare incidence and prevalence across countries. Methodological issues include varying case definitions, study designs, and population standardizations.

How do gender differences affect stroke outcomes in Asia?add

Research indicates that women, particularly those above 60 years, experience higher dependency levels one year after ischemic stroke compared to men. Additionally, Korean studies reveal higher atrial fibrillation and diabetes prevalence among women with stroke, complicating risk assessments.

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