Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology (original) (raw)
Intestinal-Specific TNFα Overexpression Induces Crohn’s-Like Ileitis in Mice
Giorgos Bamias
PLoS ONE, 2013
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Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor-induced Crohn's-like Inflammatory Bowel Disease
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Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease
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Crohn’s Disease-Associated Mucosal Factors Regulate the Expression of TNF-like Cytokine 1A (TL1A) and its Receptors in Primary Subepithelial Intestinal Myofibroblasts and Intestinal Epithelial Cells
E. Filidou
Translational Research, 2017
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Selective Targeting of Tumour Necrosis Factor Receptor 1 Induces Stable Protection from Crohn’s-Like Ileitis in TNFΔARE Mice
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TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
Giorgos Bamias
Proceedings of the National Academy of Sciences of the United States of America, 2003
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Anti-TNFα alters the natural history of experimental Crohn's disease in rats when begun early, but not late, in disease
Laura Reingold
American Journal of Physiology - Gastrointestinal and Liver Physiology, 2016
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Metabolic Phenotyping of the Crohn's Disease-like IBD Etiopathology in the TNFΔARE/WT Mouse Model
Lisa Gruber
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TNF- neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
Giorgos Bamias
Proceedings of the National Academy of Sciences, 2003
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Effect of Anti-TNF Therapy on Mucosal Apoptosis Genes Expression in Crohn's Disease
Marzena Skrzypczak-zielinska
Frontiers in Immunology, 2021
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Mucosal gene expression changes induced by anti‐TNF treatment in inflammatory bowel disease patients
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A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis
Courtney Kurtz
The Journal of Immunology, 2008
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Tumor Necrosis Factor’s Pathway in Crohn’s Disease: Potential for Intervention
Fabio Cominelli
International Journal of Molecular Sciences, 2021
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Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage
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Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease
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Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model?
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Host and microbiota interactions are critical for development of murine Crohn's-like ileitis
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Role of TNFSF15 in the intestinal inflammatory response
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World Journal of Gastrointestinal Pathophysiology
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Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
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Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice
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Journal of immunology (Baltimore, Md. : 1950), 2015
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Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways
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Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo
Eleni Douni
European Journal of Immunology, 2002
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Tumour necrosis factor in mouse models of chronic intestinal inflammation
Christoph Mueller
Immunology, 2002
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Journal of Clinical & Cellular Immunology, 2012
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Role of β7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease
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Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn’s disease through IFNα pathway
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A Novel Murine Model of Inflammatory Bowel Disease and Inflammation-Associated Colon Cancer with Ulcerative Colitis-Like Features
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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
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Pathogenesis of Crohn's disease: Bug or no bug
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