Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A (original) (raw)

Profile image of Tzyy LiangTzyy Liang

1982, Journal of The American Chemical Society

visibility

…

description

8 pages

link

1 file

Feeding of [l-I3C]acetate to cultures of Streptomyces cinnamonensis gave monensin A labeled at carbons 7, 9, 13, 19, and 25, as established by 13C N M R analysis. Similarly, incorporation of [l-13C]propionate resulted in enrichment of carbons 1, 3, 5 , 11, 17, 21, and 23. Further incorporations of [ 1,2-I3C2]acetate, [1,2-13C2]propionate, [2-13C]propionate,