Cyclic dermorphin tetrapeptide analogues obtained via ring-closing metathesis (original) (raw)

Synthesis of Stable and Potent δ/μ Opioid Peptides: Analogues of H-Tyr- c [ d -Cys-Gly-Phe- d -Cys]-OH by Ring-Closing Metathesis

Luisa Mannina

Journal of Medicinal Chemistry, 2007

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Structure–activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Victor Hruby is to

Peptides, 2008

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Conformation-activity relationships of cyclo -constrained µ/δ opioid agonists derived from the N -terminal tetrapeptide segment of dermorphin/deltorphin

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Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring-Closing Metathesis

Peter Schiller

Chemical Biology & Drug Design, 2009

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Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide

Henry I. Mosberg

International Journal of Peptide and Protein Research, 2009

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Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers

Peter Schiller

Journal of Medicinal Chemistry, 1985

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Peptides opioides: synthèse et propriétés biologiques d'hexapeptides apparents à la dermorphine

Gianfranco Balboni

European Journal of Medicinal Chemistry, 1990

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Cyclization in Opioid Peptides

Anna Janecka

Current Drug Targets, 2013

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In Vivo Cleavability of a Disulfide-Based Chimeric Opioid Peptide in Rat Brain

Ulrich Bickel

Bioconjugate Chemistry, 1995

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Opioid peptides. Synthesis and biological properties of dermorphin related hexapeptides

Roberto Tomatis

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Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues

Jessica Anand

Biopolymers, 2014

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Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligard with high delta opioid receptor selectivity and affinity

Henry I. Mosberg

Life Sciences, 1988

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New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors

Richard Agnes

2003

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Conformational analysis of enkephalin analogs contaIntng a disulfide bond Models for delta- and mu-receptor opioid agonists

Victor Hruby

International Journal of Peptide and Protein Research, 2009

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Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

Peter Schiller

Chemical Biology & Drug Design, 2012

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Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore

Arijit Sarkar

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Development of Centrally Acting Peptide Analogs: Structure-Transport Studies and Pharmacological Evaluation of Analogs of the Opioid Peptide Dynorphin A

Amanda Carey

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Opioid peptides: synthesis and biological properties of [(N?-glucosyl,N?-methoxy)-?,?-diamino-(S)-butanoyl]4-deltorphin-1-neoglycopeptide and related analoguesWith the exception of d-Ala the amino acid residues are of l-configuration. Standard abbreviations for amino acid derivatives and peptides...

elisa giannini

Organic & Biomolecular Chemistry, 2003

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Recent developments in the design of receptor specific opioid peptides

Victor Hruby is to

Medicinal Research Reviews, 1989

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δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

Delia Picone

Molecular Medicine, 1995

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Design and Comprehensive Conformational Studies of Tyr 1 -cyclo( d Pen 2 Gly 3 -Phe 4 - l -3-Mpt 5 ) and Tyr 1 -cyclo( d Pen 2 Gly 3 -Phe 4 - d -3-Mpt 5 ): Novel Conformationally Constrained Opioid Peptides

Steve Kolodziej, Garland Marshall

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Recent Progress Towards Pharmaceutical Applications of Disulfide-Rich Cyclic Peptides

Christina Schroeder, Joakim Swedberg

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Combined use of NMR, distance geometry and MD calculations for the conformational analysis of opioid peptides of the type [D(L)Cys2, D(L)Cys5]enkephalin

Fritz Andreae

International Journal of Peptide and Protein Research, 2009

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δ-Selective Opioid Peptides Containing a Single Aromatic Residue in the Message Domain: An NMR Conformational Analysis

Delia Picone

Journal of Peptide Science, 1996

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Conformational analysis of enkephalin analogs containing a disulfide bond. Models for delta- and mu-receptor opioid agonists

Victor Hruby is to

International journal of peptide and protein research, 1989

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Opioid peptides: synthesis and biological properties of [(Nγ-glucosyl,Nγ-methoxy)-α,γ-diamino-(S)-butanoyl]4-deltorphin-1-neoglycopeptide and related analogues

elisa giannini

Organic Biomolecular Chemistry, 2003

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Novel Opioid Peptide Derived Antagonists Containing (2 S )-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2 S )-Mdcp]

Peter Schiller

Journal of Medicinal Chemistry, 2008

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