Scanning the Genome for Essential Hypertension Loci (original) (raw)

1998, Clinical and Experimental Pharmacology and Physiology

1. Essential hypertension occurs in people with an underlying genetic predisposition \rho subject thernselves to adverse en. vironmental influences, The number of genes involved is unknown, as is the extent to which each contributes to final blood pressure and the severity of the disease. 2. In the past, studies of potential candidate genes have been performed by association (case-control) analysis of unrelated individuals or linkage (pedigree or sibpair) analysis of families. Th€se studies have r'€sulted in several positive findings but as one may expect, also an enormous number of negatiye r€sults. 3. In ord€r to uncover the major genetic loci for essential hypertension, it is proposed that scanning the genome systematically in 100-200 alTected sibships should prove successful. 4. This involves genotyping sets of hypertensive sibships to determine their complement of several hundred microsatellite polymorphisms, Those that are highly informative, by having a high heterozygosity, are most suitable. Also, the markers need to be spaced sumciendy evenly across the geDome so as to ensure adequate coverage. 5. Tests are performed to determine increased segregation of alleles of each marker llith hypertension. The analytical tools involve specialized statistical prograrns that can detectsuch differences. Non-parametric multipoint analysis is an appropriate approach. 6, In this way, loci for essential hlpertension are beginning to emerge,

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