The PREDICT Study: A Randomized Double-Blind Comparison of Contrast-Induced Nephropathy After Low- or Isoosmolar Contrast Agent Exposure (original) (raw)

C ontrastinduced nephropathy (CIN) is usually defined as a sudden, rapid deterioration in renal status after administration of iodinated contrast medium with no alternative clinical explanation [1, 2]. The incidence of CIN in patients with normal renal function is less than 3% but can be much higher in individuals with one or more risk factors for CIN (12-50%) [3-7]. Most studies define CIN as an increase in the serum creatinine value (≥ 0.5 mg/dL, ≥ 25%, or both) or a diminution of renal function identified by a decrease in creatinine clear ance or the estimated glomerular filtration rate (GFR) 2-3 days after contrast medium exposure [8, 9]. Recently, investigators have