Optimal doses of caspofungin during continuous venovenous hemodiafiltration in critically ill patients (original) (raw)

The study investigates the pharmacokinetics of caspofungin in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHD). Twelve patients were analyzed, revealing that caspofungin clearance was negligible in CVVHD and found that the standard dosing regimen might be inadequate for achieving therapeutic drug concentrations, particularly against certain Candida species. Results indicated that modifications to dosing could be necessary to improve therapeutic outcomes in this patient population.