Self-assembled diphenylalanine peptide microtubes covered by reduced graphene oxide/spiky nickel nanocomposite: An integrated nanobiomaterial for multifunctional applications (original) (raw)
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Journal of Applied Physics
Piezoelectric diphenylalanine peptide nanotubes (PNTs) have recently been demonstrated in energy harvesting applications, typically based on vertically aligned PNTs that generate charge when pressed. In this work, we use a wettability difference and an applied electric field to align PNTs and PNT-based composites on flexible substrates. Open-circuit voltages and short-circuit currents exceeding 6 V and 60 nA, respectively, are achieved by bending the substrate, opening up the use of horizontally aligned PNTs as flexible energy harvesting substrates.
Peptide Nanotube-Modified Electrodes for Enzyme−Biosensor Applications
Analytical Chemistry, 2005
The fabrication and notably improved performance of composite electrodes based on modified self-assembled diphenylalanine peptide nanotubes is described. Peptide nanotubes were attached to gold electrodes, and we studied the resulting electrochemical behavior using cyclic voltammetry and chronoamperometry. The peptide nanotube-based electrodes demonstrated a direct and unmediated response to hydrogen peroxide and NADH at a potential of +0.4 V (vs SCE). This biosensor enables a sensitive determination of glucose by monitoring the hydrogen peroxide produced by an enzymatic reaction between the glucose oxidase attached to the peptide nanotubes and glucose. In addition, the marked electrocatalytic activity toward NADH enabled a sensitive detection of ethanol using ethanol dehydrogenase and NAD + .
Bioinspired peptide nanotubes: deposition technology, basic physics and nanotechnology applications
Journal of Peptide Science, 2011
Synthetic peptide monomers can self-assemble into PNM such as nanotubes, nanospheres, hydrogels, etc. which represent a novel class of nanomaterials. Molecular recognition processes lead to the formation of supramolecular PNM ensembles containing crystalline building blocks. Such low-dimensional highly ordered regions create a new physical situation and provide unique physical properties based on electron-hole QC phenomena. In the case of asymmetrical crystalline structure, basic physical phenomena such as linear electro-optic, piezoelectric, and nonlinear optical effects, described by tensors of the odd rank, should be explored. Some of the PNM crystalline structures permit the existence of spontaneous electrical polarization and observation of ferroelectricity. The PNM crystalline arrangement creates highly porous nanotubes when various residues are packed into structural network with specific wettability and electrochemical properties.
Coupling of Carbon and Peptide Nanotubes
Journal of the American Chemical Society, 2014
Two of the main types of nanotubular architectures are the single-walled carbon nanotubes (SWCNTs) and the self-assembling cyclic peptide nanotubes (SCPNs). We here report the preparation of the dual composite resulting from the ordered combination of both tubular motifs. In the resulting architecture the SWCNTs can act as templates for the assembly of SCPNs that engage the carbon nanotubes noncovalently via pyrene "paddles", each member of the resulting hybrid stabilizing the other in aqueous solution. The particular hybrids obtained in the present study formed highly ordered oriented arrays and display complementary properties such as electrical conductivity. Furthermore, a self-sorting of the cyclic peptides towards semiconducting rather than metallic SWCNTs is also observed in the aqueous dispersions. It is envisaged that a broad range of exploitable properties may be achieved and/or controlled by varying the cyclic peptide components of similar SWCNT/SCPN hybrids. ACS Paragon Plus Environment Journal of the American Chemical Society Full experimental details of synthesis and characterization (NMR, HPLC, MS, etc.), and further details of VisUV, NIR, fluorescence, Raman and AFM characterization, can be found online in the supporting information. ASSOCIATED CONTENT Supporting Information. Supplementary figures and details on experimental procedures. This material is available free of charge via the Internet at http://pubs.acs.org.
Bioinspired Nanoplatforms Based on Graphene Oxide and Neurotrophin-Mimicking Peptides
Membranes
Neurotrophins (NTs), which are crucial for the functioning of the nervous system, are also known to regulate vascularization. Graphene-based materials may drive neural growth and differentiation, and, thus, have great potential in regenerative medicine. In this work, we scrutinized the nano–biointerface between the cell membrane and hybrids made of neurotrophin-mimicking peptides and graphene oxide (GO) assemblies (pep−GO), to exploit their potential in theranostics (i.e., therapy and imaging/diagnostics) for targeting neurodegenerative diseases (ND) as well as angiogenesis. The pep−GO systems were assembled via spontaneous physisorption onto GO nanosheets of the peptide sequences BDNF(1-12), NT3(1-13), and NGF(1-14), mimicking the brain-derived neurotrophic factor (BDNF), the neurotrophin 3 (NT3), and the nerve growth factor (NGF), respectively. The interaction of pep−GO nanoplatforms at the biointerface with artificial cell membranes was scrutinized both in 3D and 2D by utilizing ...
International Journal of Peptide Research and Therapeutics, 2018
The strong piezoelectricity in diphenylalanine peptide develops its technological potential as a smart material. To achieve insight into the vertical alignment of size-controlled self-assembled diphenylalanine peptide nanotubes, an aromatic peptide of diphenylalanine (FF) was applied in this research as the model peptide. Here we found for the first time a vertical alignment of size-controlled self-assembled diphenylalanine peptide nanotubes during the peptide self-assembly process of nanotubes composite using polyethersulfone (PES) membrane in situ and ex situ peregnation of peptide nano tube. The membrane structure was investigated using fluofenamic acid as a fluorescent tag and a first-line solution containing dipeptides and hexafluoropropane (HFP). The results showed a vertical alignment of size-controlled self-assembled diphenylalanine peptide nanotubes formation on silicon. The STM and SEM results indicated the formation of different nanostructures including short nanorods, nanotubes branched nanotubes and dendritic nanostructures of peptide in PES membrane. Our novel approach based on the PES membrane and HFP allows one to controllably fabricate various peptide-based nanostructures on silicon.
Nanomaterials
The structures and properties of the diphenylalanine (FF) peptide nanotubes (PNTs), both L-chiral and D-chiral (L-FF and D-FF) and empty and filled with water/ice clusters, are presented and analyzed. DFT (VASP) and semi-empirical calculations (HyperChem) to study these structural and physical properties of PNTs (including ferroelectric) were used. The results obtained show that after optimization the dipole moment and polarization of both chiral type L-FF and D-FF PNT and embedded water/ice cluster are enhanced; the water/ice cluster acquire the helix-like structure similar as L-FF and D-FF PNT. Ferroelectric properties of tubular water/ice helix-like cluster, obtained after optimization inside L-FF and D-FF PNT, as well of the total L-FF and D-FF PNT with embedded water/ice cluster, are discussed.
Nanoscale, 2010
We demonstrate that nanotubular networks formed by enzyme-triggered self-assembly of Fmoc-L 3 (9-fluorenylmethoxycarbonyl-tri-leucine) show significant charge transport. FT-IR, fluorescence spectroscopy and wide angle X-ray scattering (WAXS) data confirm formation of b-sheets that are locked together via p-stacking interactions. Molecular dynamics simulations confirmed the p-p stacking distance between fluorenyl groups to be 3.6-3.8
Applied Physics Letters, 2015
In this letter, we report on the evaluation of diphenylalanine (FF), dityrosine (YY), and phenylalaninetryptophan (FW) self-assembled peptide nanotube structures for electronics and photonics applications. Realistic bulk peptide nanotube material models were used in density functional theory calculations to mimic the well-ordered tubular nanostructures. Importantly, validated functionals were applied, specifically by using a London dispersion correction to model intertube interactions and a range-separated hybrid functional for accurate bandgap calculations. Bandgaps were found consistent with available experimental data for FF, and also corroborate the higher conductance reported for FW in comparison to FF peptide nanotubes. Interestingly, the predicted bandgap for the YY tubular nanostructure was found to be slightly higher than that of FW, suggesting higher conductance as well. In addition, the band structure calculations along the high symmetry line of nanotube axis revealed a direct bandgap for FF. The results enhance our understanding of the electronic properties of these material systems and will pave the way into their application in devices. V