Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T) (original ) (raw )2'5'-Bis-O-(tert-Butyldimethylsilyl)-3'Spiro5''- (4''Amino 1'',2''-Oxathiole-2'',2''Dioxide)Pyrimidine (TSAO) Nucleoside Analogues: Highly Selective Inhibitors of Human Immunodeficiency Virus Type 1 that are Targeted at the Viral Reverse Transcriptase
Ana Felix
Proceedings of The National Academy of Sciences, 1992
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An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives
koen andries
Proceedings of the National Academy of Sciences, 1991
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Antimicrobial Agents and Chemotherapy, 1995
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HIV Therapy, 2009
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Abasic Analogues of TSAO-T as the First Sugar Derivatives That Specifically Inhibit HIV-1 Reverse Transcriptase
Carlos Pérez
Journal of Medicinal Chemistry, 1998
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Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme †
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Journal of Medicinal Chemistry, 2007
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Novel Thiazolidin-4-ones as Potential Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
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Molecules, 2019
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Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase
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ACS Medicinal Chemistry Letters, 2013
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Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnuc...
Mj Perez
Proceedings of the National Academy of Sciences, 1993
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Novel Non-nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1)
palayakotai R raghavan
Journal of Medicinal Chemistry
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[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1
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Antimicrobial Agents and Chemotherapy, 1992
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HEPT derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase: QSAR studies agree with the crystal structures
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Journal of computer-aided molecular design, 2002
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Truncated Reverse Isoxazolidinyl Nucleosides: A New Class of Allosteric HIV-1 Reverse Transcriptase Inhibitors
Roberto Romeo
ChemMedChem, 2012
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Slow, Tight-Binding HIV1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants
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Chemmedchem, 2007
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TSAO Compounds: The Comprehensive Story of a Unique Family of HIV 1 Specific Inhibitors of Reverse Transcriptase
Ana Felix
Current Topics in Medicinal Chemistry, 2004
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Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors
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Antimicrobial Agents and Chemotherapy, 1992
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[d4U]-Spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase
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Bioorganic & Medicinal Chemistry, 2010
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Angewandte …, 2007
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Bioorganic & Medicinal Chemistry, 2011
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Lady Belmont
1997
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TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization
Ana San Felix
Antiviral chemistry & chemotherapy, 2005
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