Mast cells and eosinophils: the “hallmark” of asthma (original) (raw)

Asthma is a chronic inflammatory disease associated with airway remodeling, characterized by the involvement of various inflammatory and structural cells. This review discusses the roles of mast cells and eosinophils in tissue repair and fibrosis within the asthmatic airway. Evidence suggests that these cells not only participate in allergic reactions but also contribute to fibrotic processes through interactions that promote fibroblast activation and collagen synthesis. In particular, the review highlights the role of nerve growth factor as a mediator in tissue remodeling and emphasizes the need for further studies to explore targeted therapeutic options.