Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats (original) (raw)

International Journal of Physiology and Pathophysiology, 2013

Abstract

ABSTRACT In vitro experiments on the mitochondria isolated from adult normotensive and spontaneously hypertensive rat hearts, an increased sensitivity of mitochondrial permeability transition pore (mPTP) to Ca2+, its natural inducer, has been revealed. In spontaneously hypertensive rats, it is evoked by the reduction of active ion concentration by two orders, which causes organelle swelling. Calcium-induced swelling of the mitochondria isolated from the normotensive rats (control) is completely prevented by cyclosporin A (10 5 mol/l), a natural mPTP inhibitor, while in spontaneously hypertensive rats, it is prevented only partially (by 54%), indicating the presence of cyclosporin A-insensitive mPTP component. The results obtained give reason to conclude that hypertension is associated with mitochondrial dysfunction, characterized, in particular, by increased mPTP sensitivity to Ca2+, which may elicit widespread tissue damage, accompanying diseases of the cardiovascular system, especially hypertension. KEY WORDS: mitochondrial permeability transition pore, heart, hypertension, rats

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