MON-278 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide regulates calcium-induced mPTP opening in adult and old rat hearts (original) (raw)

FEBS letters

Abstract

Hydrogen sulfide (H2S) is a biologically active gasotransmitter, which regulates a lot of important physiological functions in the body. In the cardiovascular system H2S de novo synthesis in belongs to pyridoxal-5-phosphate-dependent enzymes – cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST). The modulation of endogenous H2S generation in the cardiovascular system and other tissues and the functional consequence of this modulation are not clear. The formation of non-selective calcium-dependent cyclosporin-sensitive permeability transition pore (mPTP) between the outer and inner mitochondrial membranes is the basis for induction of the cell death by apoptosis. The aims of this study were to elucidate the mechanisms underlying the cardioprotective effects of H2S in aging rats. Exogenous hydrogen sulfide in physiological concentrations depressed Ca2+-induced mPTP opening in a dose-dependent fashion in adult and rat hearts. Prei...

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