Rapid Identification of Staphyloccocus aureus in Positive-Testing Blood Cultures by Slidex Staph Plus Agglutination Test (original) (raw)

Chapter 1 introduction Chapter 2.1 Accuracy of identification and susceptibility results by direct inoculation of Vitek 2 cards from positive bACTEC cultures Chapter 2.2 Rapid identification of staphyloccocus aureus in positive blood cultures by slidex staph Plus ® agglutination test Chapter 3 Detection of Methicillin-Resistant staphylococcus aureus in a low-prevalence setting by PCR with a selective enrichment broth Chapter 4 Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen directed antibiotic use. Chapter 5 The cost of rapid bacterial identification and susceptibility testing Chapter 6 The effect of infectious disease consultancy and microbiological results on microbiologically correct antibiotic therapy. Chapter 7 needle to incubator time: factors influencing transport times of blood culture specimens Chapter 8 Direct incubation of blood cultures outside routine opening hours accelerates antibiotic switch Chapter 9 summary and concluding remarks Samenvatting en conclusie Dankwoord Curriculum Vitae Publicaties Chapter 1 introduction introduction 9 introduction The aim of this thesis is to validate new rapid diagnostic tests and to investigate if improving microbiological diagnostics influences patient outcome and management. Therefore a short introduction in the underlying clinical syndrome is warranted. sepsis is a major complication of infection with a high morbidity and mortality. Table 1 shows the diagnostic criteria of sepsis and severe sepsis (20). in their review Angus and Wax (3) cited several studies that reported mortality rates varying from 20 to 52%. From a point prevalence survey of Van Gestel et al. (66) it was calculated that the annual number of admissions for severe sepsis in Dutch iCUs was 8643 ± 929 cases/year, which represents 0.054% of the Dutch population, 0.61% of hospital