Leveraging Comparative Genomics to Identify and Functionally Characterize Genes Associated with Sperm Phenotypes inPython bivittatus(Burmese Python) (original) (raw)
2016, Genetics Research International
Comparative genomics approaches provide a means of leveraging functional genomics information from a highly annotated model organism’s genome (such as the mouse genome) in order to make physiological inferences about the role of genes and proteins in a less characterized organism’s genome (such as the Burmese python). We employed a comparative genomics approach to produce the functional annotation ofPython bivittatusgenes encoding proteins associated with sperm phenotypes. We identify 129 gene-phenotype relationships in the python which are implicated in 10 specific sperm phenotypes. Results obtained through our systematic analysis identified subsets of python genes exhibiting associations with gene ontology annotation terms. Functional annotation data was represented in a semantic scatter plot. Together, these newly annotatedPython bivittatusgenome resources provide a high resolution framework from which the biology relating to reptile spermatogenesis, fertility, and reproduction c...
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