Recent advances in neurokinin-3 receptor antagonists (original) (raw)
Neurokinin Agonists and Antagonists
P. D'Orléans-Juste
Annals of the New York Academy of Sciences, 1991
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Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 2. Identification of (S)-N-(1-Phenylpropyl)-3-hydroxy-2- phenylquinoline-4-carboxamide (SB 223412)
Mario Grugni
Journal of Medicinal Chemistry, 1999
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2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor
M. Vassallo
Journal of Medicinal Chemistry, 1996
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Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework
Mario Grugni
Journal of Medicinal Chemistry, 1997
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Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor
Andrew McElroy
Journal of Medicinal Chemistry, 1992
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SR 48968, a neurokinin A (NK2) receptor antagonist
tiziano croci
Regulatory Peptides, 1993
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Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs
Mario Grugni
Journal of Pharmacology and Experimental Therapeutics, 2002
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Evidence that the proposed novel human "neurokinin-4" receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin
Peter J. Buckley
Molecular pharmacology, 2000
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Neurokinin NK 1 and NK 3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain
G. Sanger
British Journal of Pharmacology, 2004
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Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig
Clive Gentry
Neuroscience, 1998
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Comparison of the effects of (±) CP 96,345 and L-668,169 on neurokinin receptor mediated responses in rat and guinea-pig isolated tissues
Zerin Razzaque
Neuropeptides, 1993
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Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist
Joost Duppen
Journal of Medicinal Chemistry, 2011
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New quinoline NK3 receptor antagonists with CNS activity
William Martin
Bioorganic & Medicinal Chemistry Letters, 2009
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Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics
Jolien De Neve
Molecules, 2021
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Possible Mechanism of Action of Neurokinin-1 Receptors (NK1R) Antagonists
Özüm Öztürk, Esin Akı, Ozum Ozturk, Andry Nur Hidayat, Kayhan Bolelli
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Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?
Patrycja Kleczkowska
Pharmacology & Therapeutics, 2018
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Spiro-piperidine non-peptide neurokinin-1 receptor antagonists
Stephen Watson
Bioorganic & Medicinal Chemistry Letters, 1995
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Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat
R. Couture
Life Sciences, 1988
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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration
Andrew Owens
Journal of Medicinal Chemistry, 2001
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Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor
Dianne Bryce
The Journal of pharmacology and experimental therapeutics, 1996
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Selective agonists for substance P and neurokinin receptors
P. D'Orléans-Juste
Neuropeptides, 1987
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Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist
Samira Daoui
Canadian Journal of Physiology and Pharmacology, 2002
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Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions
Erika Pintér, Zsófia Hajna, Gábor Pozsgai
British Journal of Clinical Pharmacology, 2014
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SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization
Samira Daoui
Journal of Pharmacology and Experimental Therapeutics, 2002
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N Eurokinin 1 R Eceptor a Ntagonists as P Otential a Ntidepressants
Charles Nemeroff
Annual Review of Pharmacology and Toxicology, 2001
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Peripheral effects of three novel non-peptide tachykinin NK1 receptor antagonists in the anaesthetized rat
R. Couture
European Journal of Pharmacology, 1996
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Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists
Joe Dupere
Regulatory Peptides, 1993
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Oral anti-hyperalgesic and anti-inflammatory activity of NK1 receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig
Clive Gentry
Pain, 2000
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GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors
Steve Arkinstall
Neuropeptides, 1994
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Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat
Réjean Couture
European Journal of Pharmacology, 1993
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Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists
François Petitet
British Journal of Pharmacology, 1993
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