Telomeric G-quadruplexes are a substrate and site of localization for human telomerase (original) (raw)

Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA

Mini-Reviews in Medicinal Chemistry MRMC

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Formation of a Stacked Dimeric G-Quadruplex Containing Bulges by the 5′-Terminal Region of Human Telomerase RNA (hTERC)

Anh Phan

Biochemistry, 2014

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Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

Takumi Ishizuka

Journal of Biological Chemistry, 2012

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Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex

Pallabi Sengupta

RSC Adv., 2017

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Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA

John Nicoludis

2012

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Resistance to the Short Term Antiproliferative Activity of the G-quadruplex Ligand 12459 Is Associated with Telomerase Overexpression and Telomere Capping Alteration

laurent lacroix, Dennis Gomez

Journal of Biological Chemistry, 2003

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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

J. Lingner, A. De Cian

Proceedings of the National Academy of Sciences, 2007

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Sean Kerwin, Laurence Hurley

Journal of Medicinal Chemistry, 1997

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Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence

Megan Carver

Nucleic Acids Research, 2007

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Deciphering the DNAzyme Activity of Multimeric Quadruplexes: Insights into Their Actual Role in the Telomerase Activity Evaluation Assay

Loic Stefan, Franck Denat

Journal of the American Chemical Society, 2011

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Consecutive Formation of G‐Quadruplexes in Human Telomeric‐Overhang DNA: A Protective Capping Structure for Telomere Ends

Takumi Ishizuka

Angewandte Chemie International Edition, 2009

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Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

Anh Phan

Nucleic Acids Research, 2007

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The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

lionel guittat

PLoS ONE, 2009

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Kinetics and Structures on the Molecular Path to the Quadruplex Form of the Human Telomere

Ananya Paul

Journal of Molecular Biology, 2014

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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands

mailliet patrick

Proceedings of the National Academy of Sciences, 2002

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Targeting telomeres and telomerase

laurent lacroix

Biochimie, 2008

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Evaluation of Human Telomeric G-Quadruplexes: The Influence of Overhanging Sequences on Quadruplex Stability and Folding

Viktor Viglasky, Peter Javorsky

Journal of Nucleic Acids, 2010

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G-Quadruplex Formation Interferes with P1 Helix Formation in the RNA Component of Telomerase hTERC

laurent lacroix

ChemBioChem, 2008

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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution

Anh Phan

Nucleic Acids Research, 2007

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An integrated molecular dynamics (MD) and experimental study of higher order human telomeric quadruplexes

Luigi Petraccone

Biopolymers, 2010

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The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures

Elzbieta Izbicka

Cancer research, 2003

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Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres

Shuo Yang

Chemical Communications, 2009

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Interaction of human telomeric DNA with N-methyl mesoporphyrin IX

Jean-louis Mergny

Nucleic acids research, 2012

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Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+ Solution

Anh Phan

Journal of the American Chemical Society, 2009

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Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures

Frédéric Rosu

Journal of the American Chemical Society, 2010

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Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

Serge Bouaziz

Journal of the American Chemical Society, 2009

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Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

Isabel Correia

ChemMedChem, 2015

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Human telomerase contains two cooperating telomerase RNA molecules

Mario Amacker

The EMBO Journal, 2001

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