Reproducibility of Retinal Nerve Fiber Thickness Measurements Using the Stratus OCT In Normal and Glaucomatous Eyes (original) (raw)
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Journal of Evidence Based Medicine and Healthcare, 2015
To study the RNFL thickness measured by stratus optical coherence tomography (OCT) patients with primary open angle glaucoma (POAG) and normal subjects, analyse the quadrant which is most efficient parameter for detecting glaucomatous damage and its correlation with visual fields. MATERIAL AND METHODS: This is a cross-sectional study of 50 glaucomatous eyes and 50 normal subjects. RNFL thickness was measured in different quadrants using stratus optical coherence tomography. RESULTS: The RNFL thickness measured by OCT in 50 glaucomatous and 50 normal eyes showed that the Inferior RNFL thickness in POAG is 77.54±31.11 compared to normal subjects where Inferior RNFL thickness is 124.96±16.74 (P<0.001). The Superior RNFL thickness in POAG is 78.32±34.81 compared to normal subjects where Superior RNFL thickness is 113.86±15.07 (P<0.001). The Nasal RNFL thickness in POAG is 53.52±13.88 compared to normal subjects where Nasal RNFL thickness is 78.103±17.87 (P<0.001). The Temporal RNFL thickness in POAG is 49.72±18.01 compared to normal subjects where Temporal RNFL thickness is 60.17±12.15 (P<0.001). The Average RNFL thickness in POAG is 63.94±18.01 compared to normal subjects where Average RNFL thickness is 97.97±9.59 (P<0.001). Both mean deviation (MD) and pattern standard deviation (PSD) showed a significant correlation with all the RNFL thickness parameters in eyes with glaucoma (pearson correlation coefficient >0.4). CONCLUSION: RNFL thickness measured on OCT may serve as useful adjunct in accurately detecting glaucoma. Average and inferior RNFL thicknesses are among the most efficient parameters for detecting glaucoma correlating with the visual field changes.
British Journal of Ophthalmology, 2010
To evaluate and compare retinal nerve fibre layer (RNFL) thickness measured by direct scanning (RNFL3.45 mode) and re-sampling from datasets (NHM4 mode) of RTVue-100 optical coherence tomography (OCT). Thirty-six healthy subjects and 76 subjects with glaucoma were imaged with Stratus OCT (fast RNFL mode, RNFL3) and RTVue-100 OCT (NHM4 (RNFL1) and RNFL3.45 (RNFL2) modes). Measurement reproducibility was assessed in NHM4 and RNFL3.45 modes of RTVue-100 OCT (intraclass correlation coefficient (ICC)). Agreement between different RNFL measurements was analysed by Bland-Altman plot. The areas under the receiver operating characteristic (ROC) curves (AUCs) for discrimination between healthy and glaucoma were compared between the different RNFL measurements. Both NHM4 and RNFL3.45 modes showed excellent measurement reproducibilities (ICC 0.831-0.978). RNFL thicknesses by two different modes of the RTVue-100 OCT, and by the Stratus OCT, were correlated in all sectors, including average. There was no significant difference between RNFL1 and RNFL2 data. However, RNFL thickness in glaucomatous eyes by the RTVue-100 OCT was significantly greater than that measured by Stratus OCT. RNFL thicknesses determined by the two different modes of RTVue-100 OCT were in excellent agreement (95% limits of agreement -6.53 to 6.95 mum). All three RNFL measurements showed good glaucoma discrimination ability (AUC = RNFL1 0.970, RNFL2 0.962, RNFL3 0.971). RNFL thickness determined by direct scanning and re-sampling from datasets of RTVue-100 OCT were in good agreement. However, both measurements in glaucomatous subjects were significantly different from those with the Stratus OCT. Those findings should be considered when a patient is followed-up using different types of OCT.
IP Innovative Publication Pvt. Ltd., 2018
Aims: To quantify and compare the retinal nerve fiber thickness in normal, ocular hypertensive and glaucomatous eyes using Optical coherence tomography (OCT). Materials and Methods: Patients were divided in to three groups of 30 each for normal, ocular hypertensive and primary open angle glaucoma. Inclusion criteria were of patients between 30-70 years of age, visual acuity of 6/36 or better, Refractive error not exceeding 5D and no prior surgery. Complete eye evaluation and was done followed by OCT Scan using the protocol “Fast RNFL thickness”. RNFL thickness was assessed in 4 quadrants and statistical analysis was done using student t test and analysis of variance (ANOVA). Results: RNFL was significantly thinner in OHT eyes than in normal eyes specifically in the inferior and nasal quadrants. 12.6% decrease in RNFL thickness was seen in OHT eyes as compared to normal eyes and about 22.29% decrease in RNFL thickness in POAG eyes as compared to OHT. Conclusions: Incorporation of OCT in glaucoma practice can helped us in evaluation of optic disc, quantifying of RNFL, identifying the structural changes in RNFL and the progression of disease. The magnitude of focal RNFL thinning in OCT was related to the magnitude of decreased global indices sensitivity in glaucomatous patient. Keywords: Low coherence optical tomography, Optic disc, Retinal nerve fiber layer, Visual field
Investigative Ophthalmology & Visual Science, 2009
To evaluate and compare the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma. METHODS. This observational cohort study included 253 eyes of 253 patients. Images were obtained annually with the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) along with optic disc stereophotographs and standard automated perimetry (SAP) visual fields. The median follow-up time was 4.01 years. Progression was determined by the Guided Progression Analysis software for SAP (Carl Zeiss Meditec, Inc.) and by masked assessment of optic disc stereophotographs performed by expert graders. Random coefficient models and receiver operating characteristic (ROC) curves were used to evaluate the relationship between change in Stratus OCT parameters over time and progression as determined by SAP and/or stereophotographs. RESULTS. From the 253 eyes, 31 (13%) showed progression over time by stereophotographs and/or SAP. Mean rates of change in average RNFL thickness were significantly higher for progressors compared with nonprogressors (Ϫ0.72 m/y vs. 0.14 m/y; P ϭ 0.004), with sensitivity of 77% for specificity of 80%. RNFL parameters performed significantly better than ONH and macular thickness measurements in discriminating progressors from nonprogressors. The parameters with the largest ROC curve areas for each scanning area were inferior RNFL thickness (0.84), cup area (0.66), and inferior inner macula thickness (0.64). CONCLUSIONS. Stratus OCT RNFL parameters discriminated between eyes progressing by visual fields or optic disc photographs and eyes that remained stable by these methods and performed significantly better than ONH and macular thickness parameters in detecting change over time. (Invest Ophthalmol Vis Sci. 2009;50:5741-5748)
Japanese Journal of Ophthalmology, 2013
Purpose To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection. Methods The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial RNFL measurements performed by Cirrus OCT, with the first and last measurements separated by at least 3 years. VF testing was performed by using the Swedish interactive threshold algorithm (SITA) Standard 30-2 program of the Humphrey field analyzer (HFA) on the same day as the RNFL imaging. Both serial RNFL thicknesses and VF progression were assessed by the guided progression analysis (GPA) software program. RNFL thickness progression was evaluated by event analysis. Total deviation (TD) in the superior or inferior hemifield was also examined. Results A total of 295 OCT scans and 295 VFs were analyzed. Five eyes exhibited progression by OCT only and 8 eyes exhibited progression by VF GPA only. When the analysis was based on the combined measurement findings, progression was noted in 6 eyes. The average of the progressive hemifield TD at baseline for combined RNFL and VF progression was-3.21 ± 1.38 dB, while it was-2.17 ± 1.14 dB for RNFL progression and-9.12 ± 3.75 dB for VF progression. The average of the progressive hemifield TD indicated a significant advancement of VF progression as compared to RNFL progression (P = 0.002). Conclusions When a mild VF defect is present, OCT RNFL thickness measurements are important in helping discern glaucoma progression.