Subclinical Hypothyroidism Impact on the Characteristics of Patients with Polycystic Ovary Syndrome. A Meta-Analysis of Observational Studies (original) (raw)
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Correlation of Subclinical Hypothyroidism With Polycystic Ovary Syndrome (PCOS)
Cureus
Aim The correlation of subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) is a still insufficiently explored entity. The aim of this study was to determine the correlation between SCH and PCOS along with the impact of SCH on metabolic and hormonal parameters in women with PCOS. Methodology This cross-sectional study was conducted at the Gynecology Outpatient Department of Ziauddin Hospital Kemari, Karachi, Pakistan, from June 2019 to December 2019. A total of 90 diagnosed cases of PCOS were enrolled in the study. A non-probability consecutive sampling technique was used. After taking informed consent, participants were evaluated through clinical interviews, a questionnaire, and anthropometric measurements. The participants underwent the following assessments, i.e., transabdominal ultrasonography, hormonal profile (free testosterone, follicle-stimulating hormone, luteinizing hormone), and fasting blood sugar. Participants were divided into two groups based on thyroid-stimulating hormone (TSH) into the euthyroid group and subclinical hypothyroid (SCH) group. The Mann-Whitney test was used for comparing the two groups. Results Our results showed a significant difference in weight, body mass index (BMI), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and TSH were found in the SCH group as compared to the euthyroid group. A significant correlation of TSH with waist-hip ratio (WHR), weight, body mass index (BMI), insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) in PCOS patients. Conclusion This study showed a significant correlation of subclinical hypothyroidism with polycystic ovary syndrome. We found subclinical hypothyroidism may aggravate the insulin resistance; therefore, PCOS patients must be screened with a thyroid profile.
European Journal of Endocrinology, 2016
Objective Subclinical hypothyroidism (SCH) is encountered in 10–25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. Methods We systematically searched Medline, Scopus, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases together with reference lists from included studies. All prospective and retrospective observational cohort studies that investigated the impact of subclinical hypothyroidism on hormonal and metabolic parameters of PCOS patients were included. The methodological quality of studies was assessed with the Ottawa–Newcastle criteria. Statistical meta-analysis was performed with the RevMan 5.3 software. Results Twelve studies were finally included in the present review, which enrolled 2341 PCOS patients. Among them, 577 had subclinical hypot...
Subclinical hypothyroidism does not influence the metabolic and hormonal profile of women with PCOS
Hormone Molecular Biology and Clinical Investigation, 2017
BackgroundSubclinical hypothyroidism (SCH) is present in 5%–10% of polycystic ovary syndrome (PCOS) patients. To date, its impact on the metabolic and hormonal profile of those women remains controversial. The purpose of our study is to evaluate the impact of SCH on the glycemic, lipid and hormonal profile of PCOS patients.Materials and methodsWe conducted a prospective case control study of patients that attended the Department of Gynecological Endocrinology of our hospital.ResultsOverall, 280 women with PCOS were enrolled during a time period of 7 years (2009–2015). Twenty-one patients (7.5%) suffered from SCH. The anthropometric characteristics were comparable among women with PCOS and those with SCH + PCOS. The prevalence of acne, hirsutism and anovulation did not differ. Significant differences were observed in the 2-h oral glucose tolerance test (OGTT) (p = 0.003 for glucose and p = 0.046 for insulin). The QUICKI, Matsuda and homeostatic model assessment-insulin resistance (HO...
Fertility and Sterility, 2013
Objective: To analyze the relationship between selected clinical and metabolic parameters in young women with polycystic ovary syndrome (PCOS) and normal thyroid function or subclinical hypothyroidism (SCH). Design: A cross-sectional cohort study. Setting: Tertiary care clinic. Patient(s): Women diagnosed with PCOS according to the Rotterdam criteria (n ¼ 168). Intervention(s): Clinical, hormonal, and metabolic parameters were evaluated. SCH was defined as TSH levels of 4.5-10 mIU/L. Main Outcome Measure(s): Separately, PCOS and SCH exert adverse effects on metabolic parameters; however, in conjunction their effect is unclear. This study evaluated whether SCH in women with PCOS affects clinical, hormonal, and metabolic parameters. Result(s): The mean age of the 168 women was 24 AE 5.8 years. Mean body mass index was 33.4 AE 8.2 kg/m 2 . Thyroid function was normal in 149 women, and 19 had SCH. Only serum low-density lipoprotein cholesterol and PRL levels were significantly higher in the women with SCH (122.6 AE 25.6 mg/dL and 17.7 AE 7.7 ng/mL, respectively) compared with those with normal thyroid function (105.6 AE 33 mg/dL and 14 AE 10.3 ng/mL, respectively). Conclusion(s): In young women with PCOS, SCH is associated with higher low-density lipoprotein cholesterol levels, albeit with no changes in other lipid profile parameters, insulin resistance, or phenotypic manifestations. This study adds to current evidence supporting an association between PCOS and SCH. (Fertil Discuss: You can discuss this article with its authors and with other ASRM members at http:// fertstertforum.com/benettipintocl-hypothyroidism-polycystic-ovary-syndrome/
Hypothyroidism A possible Risk Factor for Polycystic Ovary Syndrome among Jordanian Women
Women with PCOS demonstrate hormonal disturbances and serum lipid derangements. The aim of this study is to evaluate the possible existence, or any risk of hypothyroidism on PCOS among Jordanian women. Some serum hormones were measured with determination of serum lipid alterations as parameters in patients with PCOS, hypothyroidism, and compared with clinically health controls. The higher LH level observed in both PCOS and hypothyroidism as compared to control group with no statistically significant difference between them, and this could be attributed to higher androgen levels that desensitize the hypothalamus to the progesterone negative feedback regulation mechanism, also increased serum PRL was observed in PCOS, and was significant difference with hypothyroidism and control group, and (PROG) showed no alteration between all groups, while both (FSH) and (E2) showed significant difference among all groups but their values were in normal ranges and only (25 out of 42, 59.52%) patients with PCOS had SCH when TSH level range from (< 6.5 µIU/ml and > 10 µIU/ml) as a hidden endocrine disturbance that may increases the PCOS risks and contribute enhances of some other dangerous diseases. Although, in the case of serum lipid's profiles, higher concentration of (TG) was observed in both PCOS and hypothyroidism groups with statistically significant deference, and the higher level of (T. CHOL and LDL) was noted between PCOS and hypothyroidism groups with no statistically significant difference between them, while both of which had significant difference with control group and no significant difference noted in HDL level between all groups at (P< 0.05).
Association of hypothyroidism and polycystic ovary syndrome (PCOS)
IP innovative publication pvt. ltd, 2019
Introduction: Polycystic ovarian syndrome (PCOS) and hypothyroidism are the most common endocrine disorders in women of reproductive age group and both these disorders present with complaints of menstrual irregularities like oligomenorrhoea, secondary amenorrhoea and sometimes menorrhagia. The relationship between hypothyroidism and PCOS is not clearly understood. Aim and Objective: To determine the association between thyroid profile and polycystic ovary syndrome (PCOS) Materials and Methods: This is a retrospective study on 71 patients with PCOS at Sri Ramachandra medical centre, over a period of 6 months. In this study, PCOS was diagnosed based on Rotterdam criteria and patient details regarding history, physical examination and thyroid profile were obtained. In all these patients, thyroid profile was analysed in Beckman coulter DXI 800 based on the principle CLIA. Results: Statistical analysis was done using SPSS software version 13.0. Student t test was performed and p value < 0.05 considered to be significant. The p value is not statistically correlated for TSH and age to hypothyroidism and other presenting complaints. Discussion: PCOS was more common in the age group of 26-30 years. 18% of PCOS patients diagnosed to have hypothyroidism, 4% patients found to have Sub-clinical hypothyroidism and rest 78% were euthyroid. 46% of PCOS patients presented with complaints of irregular menstrual cycle, 31% with complaints of infertility and 23% with other complaints. Conclusion: There is increased prevalence of hypothyroidism in patients with PCOS. Similarly, the coexistence of hypothyroidism and PCOS can lead to severity of complaints in hypothyroid patients. Screening for hypothyroidism in PCOS patients will decrease the morbidity. Thus improving quality of life.
Fertility and Sterility, 2011
Objective: To determine whether subclinical hypothyroidism (SCH) alters the phenotype, insulin resistance, or lipid parameters in young women with polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: Tertiary care setting. Patient(s): Sixty-two young women with PCOS and SCH (group I) and 291 euthyroid women with PCOS (group II). Intervention(s): Recording of clinical, biochemical, hormonal profile, and parameters of insulin resistance. Main Outcome Measure(s): Whether SCH has any association with clinical parameters like hirsutism, menstrual disturbances, lipid profile, and parameters of insulin sensitivity. Result(s): Mean (AESD) TSH was 7.13 AE 1.28 IU/L in group I and 2.51 AE 1.21 IU/L in group II, with comparable free triiodothyronine and free thyroxine. The two groups were comparable in age, weight, and body mass index. Parameters like blood pressure, menstrual pattern, and degree and duration of hirsutism did not differ between the two groups. Serum concentrations of triglycerides were significantly higher in the SCH group compared with controls. Plasma glucose concentrations both in fasting and after oral glucose tolerance test were similar between the two groups. Fasting insulin and other parameters of insulin resistance were not altered by SCH. Conclusion(s): Mild TSH elevation in the face of normal serum free triiodothyronine and free thyroxine results in a mild increase in serum lipids. Subclinical hypothyroidism is not associated with alteration in phenotypic expression and insulin resistance in young women with PCOS. (Fertil Steril Ò 2011;95:2039-43.
Diagnostics
Despite solid evidence regarding the association of over-hypothyroidism with polycystic ovary syndrome (PCOS), the relationship between PCOS and subclinical hypothyroidism (SCH) is still a topic of debate. In the present population-based study, we aimed to assess if there is a difference between PCOS and the control group regarding the upper reference limit of thyroid stimulating hormone (TSH). We also aimed to identify the prevalence of SCH in women with PCOS compared to controls. This study was conducted on data collected in the Iranian PCOS prevalence study and the Khuzestan PCOS prevalence study. Participants that met our eligibility criteria were categorized into two groups: PCOS (n = 207) and control (n = 644). Quantile and logistic regression models were used to explore the effect of PCOS status on TSH cut-off values and SCH, respectively. The 95 percentiles of TSH were not significantly different in the PCOS group compared to control ones (6.12 and 6.56 microU/mL, respective...
Journal of Reproduction & Infertility, 2017
Background: The purpose of the study was to examine whether patients with subclinical hypothyroidism (SCH) should be excluded before making a diagnosis of polycystic ovary syndrome (PCOS). Methods: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Continuous variables were compared by one-way analysis of variance. Proportions were compared using Z test. Fisher test was used to compare categorical variables. Simple correlation was performed using Spearman’s coefficient. Correlation between thyroid stimulating hormone (TSH) and dependent variables were performed using backward multiple regression. The significance level was set at 0.05. Results: True polycystic ovary and polycystic ovary with subclinical hypothyroidism patients presented similar anthropometrical parameters. C-peptide was higher in polycystic ovary patients than in the other g...
Association of hypothyroidism and polycystic ovarian syndrome: a study in a semi urban area
International Journal of Advances in Medicine
Background: Polycystic ovarian syndrome reported to be one of the most common endocrine disorders in the women of the reproductive age, causing oligoovulatory infertility. In many cases, apparently healthy looking women are being diagnosed with either subclinical or overt hypothyroidism after having the symptoms of PCOS. This study was done to analyse the association of PCOS and hypothyroidism in our geographical area.Methods: 50 women of reproductive ages between 18 to 45 years, who were diagnosed with PCOS, based on Rotterdam’s criteria, 2003 and 50 healthy women as controls, were included into the study. After taking the demographic details from all the patients, they were all subjected to ultrasound for the detection of the cysts. Blood was collected for various biochemical tests including the thyroid profile. Results: The mean age of all the patients in the study group was 23.6±7.2 compared to 27.1±4.6 of the healthy controls. The Body Mass Index amongst both the groups was 29....