Incidence, clinical characteristics and early treatment outcome in Indian patients of childhood acute lymphoblastic leukemia with ALL1 gene rearrangement (original) (raw)

This study investigates the incidence, clinical characteristics, and treatment outcomes of childhood acute lymphoblastic leukemia (ALL) with a focus on ALL1 gene rearrangements in Indian patients. Among 185 cases analyzed, the prevalence of ALL1 rearrangements was assessed alongside clinical factors at presentation and treatment responses. The findings indicate high treatment response rates, but no significant correlation between ALL1 gene status and remission outcomes, highlighting the complexity of ALL's biological behavior in the Indian context.