The Role of Vitamin D in Cancer Prevention (original) (raw)

Vitamin D and Cancer Prevention

Current Nutrition Reports, 2012

Vitamin D and its potential role in the prevention of cancer have received widespread attention in recent years. A broad range of potential vitamin Drelated mechanisms affecting carcinogenesis have been identified. Epidemiology now provides evidence for a cancer protective role of elevated levels of serum vitamin D, particularly for colorectal cancer, and less clearly for breast cancer, while for many other cancers, including cancer of the prostate, no associations have been demonstrated. There continues to be a gap between results from observational trials assessing vitamin D status and those from randomized trials of vitamin D supplementation that cannot be resolved easily. However, whether new randomized trials on vitamin D and cancer development should be conducted in the future remains debatable.

Vitamin D for Cancer Prevention and Survival

Clinical Reviews in Bone and Mineral Metabolism, 2009

Higher levels of the principal circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence and death rates from colon, breast, and ovarian cancer, with a linear dose–response gradient. The accumulated evidence from observational studies and a randomized trial reveal that population serum levels of 25(OH)D in the range of 40 to 50 ng/ml will markedly reduce incidence and mortality rates of several cancers including those of the breast, colon, and ovary. There is an immediate clinical need for cancer care providers worldwide to assure that a serum 25(OH)D level >40 ng/ml is achieved as soon as feasible after diagnosis of patients with breast and colon cancer, unless specifically contraindicated by pre-existing hypercalcemia. This serum target could be revisited after further rigorous studies are performed, but the evidence that has accumulated during the past 29 years is sufficiently strong now to adopt the above dosages and serum targets for professional and public health action. Such prompt action is likely to cut mortality from these cancers by half within approximately 5 years. Research on a wider range of cancer types with higher serum 25(OH)D levels (≥50 ng/ml or 125 nmol/l) is needed. In the meantime, vitamin D3 intake by everyone in the continental US and Canada aged 1 year and older should not be less than 2000 IU/day of vitamin D3, and 1000 IU/day for infants.

The Emerging Role of Vitamin D in Cancer Risk Reduction

2003

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Vitamin D for Cancer Prevention: Global Perspective

Annals of Epidemiology, 2009

Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers. Epidemiological findings combined with newly discovered mechanisms suggest a new model of cancer etiology that accounts for these actions of 25(OH)D and calcium. Its seven phases are disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition (abbreviated DINOMIT). Vitamin D metabolites prevent disjunction of cells and are beneficial in other phases. It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such ...

Relationship between vitamin D and cancer: A narrative review

Brazilian Journal of Health and Biomedical Sciences, 2022

Introduction: Vitamin D is involved in several human metabolismpathways, both in classic pathway, which involvesthe calcium and phosphorus metabolism, and in non-classicpathways, which are related to several types of diseases, includingdiseases related to muscles; kidneys; cardiovascular system;immune system; some types of cancer; diabetes; and pregnancy.Objectives: As cancer is one of the main health problems inthe world and knowing that it is one of the non-classic effectsrelated to vitamin D, the current narrative review aimed toverify the relevance of vitamin D has on the types of cancer.Methods: The bibliographic research was performed in databasesPubmed, Scopus and PEDro on June 16, 2020, using thekeywords “vitamin D”, “cancer” and “non-classic”. Only articlessince the year 2000 were included. Thirty-one articles wereanalyzed relating vitamin D to colon/rectum cancer, breastcancer, prostate cancer, lung cancer, ovarian cancer, melanomaand other types of skin cancer, and gastri...