A Review on Vaginal Drug Delivery Systems (original) (raw)

Abstract

Some drugs are poorly absorbed after the oral administration. Over the last twenty years, extensive efforts have been made towards the administration of poorly absorbed drugs through different delivery systems and routes but the presence of a mucus laden cervix (vagina) in women provides an opportunity as a conjoint site for such drug delivery. The vaginal route has been rediscovered as a potential route for systemic delivery of various therapeutically important drugs avoid first pass metabolism. However, fruitful delivery of drugs through the vagina remains a challenge because of poor absorption of some drugs across vaginal epithelium. The various factors like vaginal physiology, age of patient, menstrual cycle are affecting the rate of drug absorption after vaginal administration. The future of vaginal drug delivery lies in the bioadhesive tablets, liposomes, niosomes and microparticles, which although relatively new and show great promise in providing truly controlled delivery of...

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