Peristomal bullous pemphigoid (original) (raw)

Bullous Pemphigoid in a 37-Year Old Female: A Case Report and Literature Review

Journal of Health and Medical Sciences

Bullous pemphigoid is a blistering disorder which mainly affects the geriatric population predominantly older than 70 years. It is caused by an autoimmune reaction to the hemidesmosomal proteins in basal keratinocytes, causing an inflammatory cascade and subsequent bullae formation. It is rarely encountered in infants, children, and middle-aged adults. Herein, a case of Bullous pemphigoid in a 37-year old female patient is reported. The patient presented with a three-month history of multiple serous fluid-filled tense blisters on the face, neck, trunk, flexor and extensor surfaces of the extremities up to the lower thigh, with areas of excoriation, peeling, erosion and crusting. No involvement of the mucous membranes noted. The lesions were associated with intense pruritus and pain upon rupture. Patient had no other subjective complaints and had an unremarkable past medical history. Patient was initially treated with antibiotics but noted no improvement in her condition. Histologic ...

A 40-year-old woman with excoriated skin lesions

Cleveland Clinic Journal of Medicine, 2011

A 40-year-old woman presents to the clinic with multiple excoriated lesions over her chest, arms, abdomen, and upper back ). The lesions have been present for many years; a few of them show signs of recent bleeding.

Reactive Perforating Collagenosis; An Uncontrolled Pruritus That Left You Scratching Your Head

Cureus, 2020

Acquired perforating collagenosis is a rare disease of altered collagen formation that is extruded through the epidermis. It is most commonly seen in patients with microvascular disease including longstanding diabetes and chronic kidney disease (CKD). Due to the rarity of the disease, no large randomized clinical studies have been performed to determine the most efficacious method of treatment. Therefore, most of the knowledge available for treatment is secondary to the information collected through case reports, case series, and retrospective analyses. In this report, we present the case of a 68-year-old male with history of stage IV CKD who presented with a severe skin rash that was present over his body, including the chest, arms, back, neck, and buttocks. It did not involve the mouth, legs, palms or soles of the feet. He did not have a significant history of diabetes and had been placed on steroids with the concern that this rash may have been secondary to a drug reaction, erythema multiforme, or bullous pemphigoid. Two skin biopsies were performed as the patient was not responding to systemic and topical steroid or oral antibiotic therapy. The final biopsy ultimately revealed a diagnosis of acquired perforating collagenosis. This is unusual in our case because although our patient had advanced CKD, he was not on dialysis, and had no significant longstanding history of diabetes. Additionally, as the prevalence of CKD is increasing in the population, it becomes more pertinent for providers to be aware of dermatological conditions associated with advanced CKD. This case report seeks to raise awareness of this disease. Furthermore, as the initial skin biopsy was unrevealing, this case also emphasizes the importance of repeating a biopsy to reduce the chance of sampling error.

A Case of Bullous Pemphigoid -Potentially Fatal Condition

https://www.ijhsr.org/IJHSR\_Vol.12\_Issue.10\_Oct2022/IJHSR-Abstract19.html, 2022

Bullous pemphigoid is a rare autoimmune skin disorder characterized by enormous, fluidfilled blisters that appear on skin lower belly, upper thighs and armpits. It occurs when the body's immune system targets the tissue layer beneath the top layer of skin. The cause of this attack is not known. A 48 years old male patient received in the ward with the complaints of fluid filled lesions all over the body including oral cavity, history of rupture of lesions spontaneously to form raw areas, itching before the onset of lesions since 3 days. The incisional biopsy was done and the lesion was clinically confirmed to be a bullous pemphigoid. After the medical treatment with steroids, the patient was symptomatically better and was discharged with medications.