In-hospital prognostic value of on admission creatinine clearance in patients with acute coronary syndrome (original) (raw)

clinical symptoms caused by acute myocardial ischemia. 1,2 ACS encompasses acute myocardial infarction (MI) [both ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI)] and unstable angina (UA). Acute MI is defined as rise of cardiac biomarkers with at least one of the following: ischemic cardiac pain, ECG changes indicative of new ischemia (ST-T change or appearance of new bundle branch block), development of pathological Q waves, imaging evidence of new loss of viable myocardium or new regional wall motion abnormality.UA is diagnosed on the basis of any one of the following criteria: rest angina, new-onset angina, and increasing angina (increasing in intensity, duration, and/or frequency). 3 Many studies have demonstrated that renal insufficiency is an independent risk factor for cardiovascular morbidity and for all-cause as well as cardiovascular death in both the general population and patients with cardiovascular disease. 4 In particular, recent studies have shown that any stage of renal dysfunction (mild to severe) is an independent risk factor for short-and long-term morbidity among patients with MI, even after administration of fibrinolytics. 4-7 However, there are limited data about this relationship in patients presenting with non-ST-segment-elevation MI and unstable angina. 8