IJBCP International Journal of Basic & Clinical Pharmacology (original) (raw)
Related papers
International Journal of Basic and Clinical Pharmacology, 2016
Background: Glucocorticosteroids, one of the common drugs used by the dermatologists brought a revolutionary change in their practice. Unfortunately steroids are misused in dermatological panacea due to dramatic relief in inflammatory and pruritic skin conditions but may lead to deleterious effects if irrationally used. Hence this study was planned to know the prescribing pattern of corticosteroids. Methods: It was a cross sectional observational study. The prescriptions of patient attending the dermatology OPD were screened for the usage of the corticosteroids. The demographic data, chief complaints, diagnosis and the details of the drugs was collected. Results: Out of 384 prescriptions screened, 14.06% were prescribed corticosteroids. Average number of drugs per prescription was 2.28±0.83. Polypharmacy (≥4 drugs) observed in 9.26% of prescriptions. Corticosteroids prescribed by generic name were 24.07% and brand name was 75.93%. Corticosteroids alone prescribed in 38.89% and along with antihistaminics/antibiotics/emollients in 61.11%. Topical corticosteroids prescribed in 79.6% and 20.4% by systemic route. Moderately potent steroids prescribed in 74.42% followed by potent (13.95%) and very potent steroids (11.63%). Patients on corticosteroid self-medication were 28%, among them 4 developed adverse reactions with severe acneiform eruptions over the face. No fixed dose combination drugs were prescribed. Conclusions: In this study we observed the rationale and safe prescribing pattern. However, the corticosteroids prescribed by brand names (75.93%) were more than generic names (24.07%), information about the strength of the steroid not mentioned and usage of emollients was less. This indicates the need for continuous medical education for the clinicians.
National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Glucocorticoids, are one of the commonly prescribed drugs in a large fraction of patients in the dermatology department. The use of corticosteroids has brought a remarkable change in the field of dermatology as these drugs afford a dramatic relief in inflammatory and pruritic skin conditions but may lead to deleterious effects if irrationally used. Moreover, the data related to drug usage pattern of corticosteroids in skin conditions is particularly lacking. Hence, it is vital to study the drug prescribing pattern of corticosteroids in skin diseases. Aims and Objective: To study the demographic details and drug prescription pattern of corticosteroids in patients with skin diseases. Materials and Methods: It was a retrospective, observational study carried out on dermatology inpatients over a period of 6 months. Case sheets of the patients were retrieved from medical record department and scrutinized systematically to know about the usage of corticosteroids in various skin conditions. Results: Out of the total 187 inpatients in whom corticosteroids were prescribed, 41.7% (n = 78) were male patients and 58.3% (n = 109) were female patients. The most common conditions for which corticosteroids prescribed were psoriasis in 30.5% patients followed by urticaria in 23.5% of patients. The topical corticosteroids were prescribed for 149 patients. Super potent topical corticosteroids were prescribed in 59.7% of patients whereas potent corticosteroids were prescribed in 26.1% of patients. None of the prescriptions used generic names. Conclusion: In this study, we observed the safe prescribing pattern for corticosteroids. However, none of the corticosteroids were prescribed by generic name. This indicates the need for continuing medical education for practicing physicians.
Study Of Corticosteroid Use In Dermatological Conditions With Adverse Effect Profile
IOSR Journals , 2019
Introduction: The ultimate goal in dermatological therapy is to use the safest and least number of drugs in order to obtain the best possible effect in the shortest period at reasonable cost. One step to achieve this is to monitor, evaluate and therapeutically analyze the prescribing pattern of dermatological drugs. Such analysis will not only improve the standards of medical treatment at all levels in the health system, but will also help in the identification of problems related to drug use such as polypharmacy,drug-drug interaction and adverse drug reactions. The ultimate outcome of the dermatological prescription analysis will be a message to the prescribing physician to achieve rational, cost-effective medical care. Aim. Evaluation of adverse effects of corticosteroids on systemic and topical administration of steroids in dermatological conditions-by monitoring prescriptions and to find the percentage incidence of adverse effects on topical, oral and both and in combination with other routes of administration. Methods: After obtaining approval from the IEC and valid informed consent, the participants were recruited into the study. This cross-sectional descriptive study was conducted in Andhra Medical College, Vishakhapatnam, Andhra Pradesh, India for 200 patients/ Five hundred prescriptions were randomly collected from the drug-dispensing counter and analyzed. The prescriptions were written by dermatologists. Data will be analyzed with respective to side effect profile. of gender wise age wise incidence will be noted. Results: Total of 200 patients got enrolled in this study, out of which 127 were female and 63 were male. Mean (±SD) age of the patients was 40.5 years (±15.0) as the age increases the incidence of adverse effects increases. Majority of the patients (n=140(70%)) have used topical corticosteroids, 60 (30%) have used corticosteroids by systemic route. The ADE through other systemic routes were also considered along with topical corticosteroids Conclusion: prescriptions were monitored for adverse effects of topical corticosteroids and steroids on systemic therapy and found that various adverse effects on topical administration are equally carries the risk of ADR The study showed that there is increase in incidence of ADRs with corticosteroids as age advances. The incidence of ADRs s also more in females when compared with males.
Objectives: To assess the utilization pattern of Corticosteroids in tertiary care teaching hospital of Bastar district, a tribal region of Chhattisgarh state at central-south India. Methods: All the prescriptions issued to the patients attending the dermatology OPD from January 2015 to March 2015 were recorded and assessed as per WHO guidelines for Drug Utilization Studies. Results: The total number of drugs prescribed in the 3650 prescriptions was 10,002 with the average number of drugs per prescription being 2.74. Corticosteroids were prescribed in 753 prescriptions (20.63% of all prescriptions). Corticosteroid is most commonly prescribed for Allergic Contact Dermatitis. Corticosteroids were most commonly given by the topical route (70.87%). Injectable Corticosteroids were prescribed only in 3.88% of total Corticosteroid use. High potency corticosteroids were prescribed most frequently (55.34%) followed by moderate potency (33.48%). Very high potency drugs were prescribed only in 63 out of 730 (8.63%). Most of the steroids were prescribed by generic names (88.98%). Duration of application was not mentioned in 62.95%. Conclusions: Use of Corticosteroids were not the top in list but adequate information was not written in some of the records with regard to the site of application, duration and quantity of the corticosteroid to be dispensed. Use of the drugs mostly by generic name is a welcome initiative towards the rationality. Prescribing practice of high potent and moderate potent topical corticosteroids was found to be high.
A Prospective Study on Usage Pattern of Corticosteroids in a Tertiary Care Hospital
International Journal of Pharmaceutical Sciences and Drug Research
Rational use of corticosteroids is very essential for improving patient safety on long term use. The present study aimed to study the prescribing usage pattern of corticosteroids in a tertiary care hospital. A prospective observational study was conducted in the department of dermatology, gynecology and general medicine in a tertiary care teaching hospital for the period of 6 months (August-February). All patients receiving any category of Steroid therapy were included and the prescribing and tapering pattern of steroids were reviewed. Prescribing pattern was observed and analysed in 132 participants during the study period. Cases were collected from the departments of Dermatology, General Medicine, Pediatrics and Gynecology in Gandhi Hospital, Secunderabad. All the prescriptions containing steroids were included in this study and the parameters evaluated were gender distribution, age of the patients, types of steroids according to the route of administration, number of prescribed d...
International Journal of Basic and Clinical Pharmacology, 2016
Topical glucocorticoids have revolutionized dermatologic therapeutics and are cornerstone of therapy in inflammatory skin diseases. Their therapeutic range varies from mild self-limiting conditions to life threatening problems. They reduce symptoms of inflammation, but do not address the underlying cause of disease. 3 The ultimate goal of dermatological therapy is to use the safest and least number of drugs in order to ABSTRACT Background: The selection of rational yet most effective treatment is an art to be learnt by most physicians. The advent of topical glucocorticoids has changed the way inflammatory dermatological conditions are managed. However, there is a constant need to keep a check on these prescriptions for their rationality. The present study was done to review the prescribing pattern of topical corticosteroids in dermatology outpatients at a tertiary care hospital. Methods: This was a prospective observational study on 300 prescriptions of patients above 18 years of age receiving topical corticosteroids in the dermatological outpatient department of a tertiary care hospital in the time frame of June 2014 to August 2014. Data obtained was recorded in a structured case record form (CRF) and analysed for their prescribing pattern, adverse reactions and cost analysis within different socioeconomic classes. Data was analysed using relevant statistical tests. A P-value of less than 0.05 was considered significant. Results: Data was collected from 300 patients with the mean age of 38.28±11 years. The most common indication for prescription of topical steroids was eczema (22.33%). The most commonly prescribed topical steroid was clobetasol (68.66%) followed by mometasone (11%), betamethasone (9.33%) and halobetasol (3%). Cream was the most frequently prescribed formulation (85.66%). 28 patients (9.33%) out of 300 showed adverse drug reactions, of which, erythema was the most common (50%). Conclusions: Topical corticosteroids are effective drugs in an array of dermatological diseases and abundant choices are available in different formulations. Optimal therapy involves careful consideration of factors such as potency, formulation, responsiveness and the cost of the topical steroid.
2020
Introduction: Skin diseases are a significant problem all over the world. Corticosteroids are one of the most commonly prescribed drugs in the skin diseases due to their anti-inflammatory and immunosuppressive actions. The appropriate use of corticosteroids is necessary to obtain best possible effect with safest and least number of drugs, while avoiding under use and abuse which may lead to subtherapeutic dose (non-responsive) and adverse effects respectively. Aim: To assess the utilization pattern of corticosteroids in the dermatology department, Jayanagar General Hospital, Bangalore, India. Methodology: A hospital based prospective observational study was carried out for a period of 6 months in Jayanagar General Hospital, by enrolling outpatients considering study criteria. Prescription with atleast one steroid were collected and analyzed for corticosteroids prescription pattern. Results: Out of 150 patients studied, majority of the prescription were of females (59.33%) compared t...
International Journal of Basic & Clinical Pharmacology, 2013
Background: Corticosteroids are a group of commonly used drugs in dermatology practice whose non judicious use frequently results in undesirable and unwanted effects. Prescribing them rationally with care allows us to derive the maximum benefit out of them with minimal side effects. Methods: Retrospective analysis of 112 case files belonging to patients admitted in the department of dermatology over a period of one year was undertaken to ascertain the usage pattern of corticosteroids in relation to their potency, strength, frequency, duration, route, quantity to be applied. The data thus collected was expressed in terms of averages, ratios and proportions. Results: The total number of formulations prescribed were 929 out of which 10.8% were corticosteroids. The average number of formulations prescribed per patient was 8.29. About 78(70%) patients admitted in dermatology received corticosteroids. Topical steroids were prescribed in 50 patients (44.7 %) out of whom 36 (72%) received only topical, the remaining 14(28%) were prescribed both systemic and topical corticosteroids. Brand names were used in all cases. Highly potent corticosteroids like clobetasol, halobetasol and mometasone were prescribed to 39(50%) of all cases who received topical corticosteroids. Conclusion: The study reveals the deficiencies which exist in the present prescribing pattern of corticosteroids. Educational interventions among the doctors as well as students should be carried out to in order to promote rational drug use.
Topical corticosteroid abuse on the face: a prospective, study on outpatients of dermatology
Our Dermatology Online, 2014
Introduction: Topical corticosteroids (TCS) are widely misused. Uncontrolled use of steroids can cause undesirable adverse effects especially on face. Aim: The aim of this study was to assess the skin manifestations of TCS misuse over the face in the patients attending dermatology outpatient and to analyze various factors contributing to such misuse. Material and Methods: A total of 200 patients with facial dermatoses using topical steroids over face for minimum period of 1 month, reported between June 2010 and May 2011 were enrolled in the study. Details about the usage of topical corticosteroids and their side effects were recorded. The patients were educated about the misuse. Results: Majority of the patients were females (71%). The most common reason for misuse was acne (61%) followed by use as a fairness cream (23%). The average duration of usage was 6 months to 1 year, longest being 8 years. The drug most commonly misused was Betamethaone Valerate (71%). The commonest side effect noted was acne form eruptions (52%) followed by steroid dependent face (SDF) (36%). There were no cases of allergic contact dermatitis or perioral dermatitis. The exacerbation of the lesions on stoppage of steroid cream (90%) fairness effect (10%) were the reasons for continued use. (100%) were unaware of side effects of topical steroids. Conclusions: Steroids have been misused by patients on their own or by doctors for various reasons. Hence the awareness about their correct usage is essential.
EVALUATION OF CORTICOSTEROID UTILIZATION PATTERN IN TERTIARY CARE HOSPITAL, DEHRADUN.
Background: Corticosteroids are widely used as potent anti-inflammatory and immunosuppressive drugs to treat a wide range of diseases. This study evaluates the rational use of corticosteroid amongst hospitalized patients. Objectives: To investigate the utilization and evaluation pattern of corticosteroids in various department of tertiary care hospital. Methodology: A prospective observational study was conducted on 90 patients receiving corticosteroids in the various departments of ShriMahantIndiresh Hospital, Dehradun, Uttarakhand. Patients receiving corticosteroid therapy were included in the study, exclusion of those patients who were of age less than 18, patients with psychiatric disease and those patients not willing to sign on inform consent form. Result: The study involved 90 patients to evaluate the appropriate use of corticosteroids. Majority of patients were of age group >60 years, followed by 41-50 years, 51-60 years, 31-40 years, 18-30 years respectively. Majority of corticosteroids were prescribed to females than males. Prednisolone was the mostly used corticosteroid (34.40%) followed by hydrocortisone (18.9%), budesonide (14.4%), methylprednisolone (11.1%), dexamethasone (11.1%), deflazacort (5.6%) and prednisone (4.4%). Total 16 ADRs were detected in the study. Total 24 drug interactions were found in 90 prescription, the majority of drug interactions were moderate 15 (62.50%) followed by major 5 (20.83%) and minor 4 (16.67%). Conclusion: There was lack of appropriate guidelines for use of corticosteroids and drug interaction reporting, which could be considered an emerging scope of pharmacy. Commonly geriatric population was more prone to diseases, for which steroids were used.