Chemoenzymatic One-Pot Synthesis of both (R)- and (S)-Aryl-1,2-ethanediols (original) (raw)
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The paper presents a novel one-pot chemoenzymatic method for synthesizing both enantiomers of aryl-1,2-ethanediols starting from simple and inexpensive achiral ethanones. The procedure successfully combines chemical and enzymatic reactions in a single operation without the need for intermediate purification, resulting in high yields and enantiomeric excess. A variety of aryl groups were tested, demonstrating the method's versatility and efficiency in producing optically active compounds relevant for organic synthesis.
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