The soluble mannose receptor is released from the liver in cirrhotic patients, but is not associated with bacterial translocation (original) (raw)

Liver international : official journal of the International Association for the Study of the Liver, 2016

Abstract

Intestinal bacterial translocation (BT) is involved in activation of liver macrophages in cirrhotic patients. Macrophages play a key role in liver inflammation and are involved in the pathogenesis of cirrhosis and complications. BT may be determined by presence of bacterial DNA (bDNA) and macrophage activation by the soluble mannose receptor (sMR). We hypothesize that sMR is released from hepatic macrophages in cirrhosis and associated with bDNA, portal pressure and complications. We investigated 28 cirrhotic patients set for transjugular intrahepatic portosystemic shunt (TIPS) insertion due to refractory ascites (n=17), acute (n=3), or recurrent variceal bleeding (n=8). We analysed plasma from the portal and hepatic veins for bDNA and sMR with qPCR and ELISA. The median sMR level was elevated in the hepatic vein compared with the portal vein (0.57(IQR0.31) vs. 0.55(0.40) mg/L, p=0.005). sMR levels were similar in bDNA-positive and -negative patients. The sMR level in the portal and...

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