Variability in emotional/behavioral problems in boys with oppositional deviant disorder or conduct disorder: the role of arousal (original) (raw)
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Journal of Affective Disorders, 2019
Background: Emotional dysregulation (ED) is a trans-nosographical condition characterized by mood instability, severe irritability, aggression, temper outburst, and hyper-arousal. Pathophysiology of emotional dysregulation and its potential biomarkers are an emerging field of interest. A Child Behaviour Checklist (CBCL) profile, defined as Dysregulation Profile (DP), has been correlated to ED in youth. We examined the association between the CBCL-DP and indices of sympathetic arousal in children with Oppositional Defiant Disorder (ODD) and healthy controls. Method: The current study sought to compare the arousal level measured via electrodermal activity in response to emotional stimuli in three non-overlapping groups of children: (1) ODD+CBCL-DP (n = 28), (2) ODD without CBCL-DP (n = 35), and (3) typically developing controls (n = 25). Results: Analyses revealed a distinct electrodermal activity profile in the three groups. Specifically, children with ODD+CBCL-DP presented higher levels of sympathetic arousal for anger and sadness stimuli compared to the other two groups. Limitations: The relatively small sample and the lack of assessing causality limit the generalizability of this study which results need to be replicated in larger, different samples. Conclusion: The CBCL-DP was associated to higher levels of arousal for negative emotions, consistently with previous reports in individuals with depression and anxiety. Further work may identify potential longitudinal relationships between this profile and clinical outcomes. 1. Introduction Children with severe dysregulation of emotions and behavior, mood instability, irritability, aggression, temper outburst, and hyperarousal are still a diagnostic challenge in clinical practice, not completely fitting any of the current clinical categories, including Disruptive Behavior Disorders (DBD) or Mood Disorders (MD) (Stringaris and Goodman, 2009). The Child Behavior Checklist (CBCL), one of the most used instruments for assessment of developmental psychopathology (Achenbach and Rescorla, 2004), has been considered a possible tool for identifying children with these features, using the Child Behavior Check List-Dysregulation Profile (CBCL-DP) (Rescorla et al., 2018). Accordingly, the CBCL-DP has become widely regarded as a measure of emotional/behavioral dysregulation (
Journal of Criminal Justice, 2018
Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD were investigated: +/-Limited Prosocial Emotions (LPE), +/-comorbid internalizing disorders (INT). Methods: Baseline ANS activity was measured by Heart Rate (HR), Heart Rate Variability (HRV; parasympathetic activity), Pre-Ejection Period (PEP; sympathetic activity), and Respiration Rate (RR). 659 females (296 CD, 363 controls) and 351 males (187 CD, 164 controls), aged 9-18 years participated. Results: Baseline HR, HRV and PEP did not differ between CD subjects and controls in both sexes. RR was higher in CD participants than controls amongst females, but not males. LPE was unrelated to ANS activity, whereas females with CD + INT presented lower HRV. Conclusions: These results suggest that baseline ANS activity is not a robust indicator for CD. However, deviant ANS activityespecially parasympathetic activity-was observed in CD females with internalizing comorbidity.
Biological Psychiatry, 1998
Background: Arousal-regulating mechanisms are important in explaining individual differences in antisocial behavior. Methods: Alterations in saliva~' cortisol concentration and cardiovascular activity were studied in 21 boys with oppositional defiant disorder (ODD) and 31 normal controis (NC) during a 2-hour stressful procedure involving frustration and prow~cation. Results: Baseline levels of heart rate (HR) were significantly lower in the ODD group, but their HR levels were higher during provocation and frustration. Cortisol levels in the ODD group were overall lower than those of the NC group, and the effect of stress seemed to be minimal and similar for both groups; however, individual differences were large. Since anxiet)' plays an important mediating role in cortisol response, subjects' were divided into one of four groups based on the intensity of their externalizing behavior and anxiousness. Cortisol increase due to stress exposure was strongest in highly externalizing and highly anxious subjects; cortisol decrease was strongest in those subjects who were high in externalizing behavior and low in anxiousness. Conclusions: The results of the study support an important role for hypothalamic-pituimry-adrenal axis sympathetic autonomic functioning in persistent antisocial behavior in young boys.
Reactive aggression in boys with disruptive behavior disorders: behavior, physiology, and affect
Journal of abnormal child psychology, 2002
This study examined responses to peer provocation in boys ages 9-13 years who met symptomatic criteria for ADHD-only, ODD/CD-only, comorbid ADHD/ODD/CD, or no diagnosis. Boys participated in a reaction-time game that included standardized verbal and behavioral provocation. Their behavioral, physiological, and affective responses to this task were measured. Results showed that groups did not differ following high levels of provocation because all boys behaved aggressively. However, following low provocation boys with comorbid ADHD/ODD/CD had higher levels of behavioral aggression, had greater heart rate acceleration, and were rated as angrier than all other boys. In addition, boys with comorbid ADHD/ODD/CD held a grudge longer than other children. Results suggest that boys with comorbid ADHD/ODD/CD are especially reactive to provocation from their peers.
Journal of Abnormal Psychology, 2006
Numerous studies have revealed autonomic underarousal in conduct-disordered adolescents and antisocial adults. It is unknown, however, whether similar autonomic markers are present in at-risk preschoolers. In this study, the authors compared autonomic profiles of 4-to 6-year-old children with attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD; n ϭ 18) with those of age-matched controls (n ϭ 20). Children with ADHD and ODD exhibited fewer electrodermal responses and lengthened cardiac preejection periods at baseline and during reward. Although group differences were not found in baseline respiratory sinus arrhythmia, heart rate changes among ADHD and ODD participants were mediated exclusively by parasympathetic withdrawal, with no independent sympathetic contribution. Heart rate changes among controls were mediated by both autonomic branches. These results suggest that at-risk preschoolers are autonomically similar to older externalizing children.
2008
Although deficiencies in emotional responding have been linked to externalizing behaviors in children, little is known about how discrete response systems (e.g., expressive, physiological) are coordinated during emotional challenge among these youth. We examined time-linked correspondence of sad facial expressions and autonomic reactivity during an empathy-eliciting task among boys with disruptive behavior disorders (n 5 31) and controls (n 5 23). For controls, sad facial expressions were associated with reduced sympathetic (lower skin conductance level, lengthened cardiac preejection period [PEP]) and increased parasympathetic (higher respiratory sinus arrhythmia [RSA]) activity. In contrast, no correspondence between facial expressions and autonomic reactivity was observed among boys with conduct problems. Furthermore, low correspondence between facial expressions and PEP predicted externalizing symptom severity, whereas low correspondence between facial expressions and RSA predicted internalizing symptom severity.
PloS one, 2016
Previous research has pointed towards a link between emotion dysregulation and aggressive behavior in children. Emotion regulation difficulties are not specific for children with persistent aggression problems, i.e. oppositional defiant disorder or conduct disorder (ODD/CD), children with other psychiatric conditions, such as autism spectrum disorders or attention-deficit/hyperactivity disorder, have emotion regulation difficulties too. On a behavioral level some overlap exists between these disorders and comorbidity is high. The aim of this study was therefore twofold: 1) to examine emotion regulation difficulties in 65 boys with ODD/CD in comparison to a non-clinical control group (NC) of 38 boys (8-12 years) using a performance measure (Ultimatum Game), parent report and self-report, and 2) to establish to what extent emotion regulation in the ODD/CD group was correlated with severity of autism and/or attention deficit traits. Results on the Ultimatum Game showed that the ODD/CD ...
Psychobiological personality traits of children and adolescents with disorders of arousal
2022
Disorders of arousal (DOA) are Non-Rem Sleep (NREM) parasomnias that emerge from incomplete arousal out of deep sleep and lead to a broad variety of emotional and motor behaviours. Increasing evidence supports the hypothesis that specific psychopathological traits contribute to the multifactorial origin of these phenomena. The aim of the current multicenter study was to compare the personality profile of children and adolescents with and without DOA using the Junior Temperament and Character Inventory (JTCI).We enrolled 36 patients with a diagnosis of DOA (mean age of 11 ± 3 years, 64% males), and 36 healthy age and gender matched control subjects (mean age of 11.2 ± 3.6, years, 67% males). Their parents completed the Paris Arousal Disorder Severity Scale (PADSS), the Sleep Disturbance Scale for Children (SDSC) and the JTCI.Patients with DOA reached significantly higher levels compared to their control group in total PADSS (p <.0001) and in total SDSC (p < 0.0001). They also d...
Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Why is low resting heart rate (HR) associated with antisocial behavior (ASB), i.e., aggression and rule breaking, in adolescence? Theory suggests that personality traits mediate this relationship but differently with age. In the present study this age-effect hypothesis is tested; we expected that the relationship between HR and aggression would be mediated in preadolescence by the personality trait behavioral inhibition, but not by sensation seeking. However, the relationship between HR and rule breaking in adolescence was predicted to be mediated by sensation seeking, but not by behavioral inhibition. Hypotheses were tested separately for boys and girls. Method: HR in supine position was assessed in repondents to the TRacking Adolescents' Individual Lives Survey (TRAILS) (N ϭ 1,752; 48.5% boys) at age 11 years. Rule breaking and aggression at age 16 were assessed with two subscales from the Youth Self Report (YSR) questionnaire. Personality (i.e., sensation seeking and behavioral inhibition) was measured at ages 11, 13.5, and 16 with the Early Adolescent Temperament Questionnaire-Revised (EATQ-R), Behavioral Inhibition System/ Behavioral Activation System (BIS/BAS) scales, or NEO Personality-Index Revised (NEO-PI-R). Results: In boys, lower HR was associated with aggression and rule breaking in adolescence. The association between HR and rule breaking was mediated by sensation seeking in adolescence but not in preadolescence. Girls' HR was not associated with ASB, and no mediating effects were found. Conclusions: Our findings support the age-effect hypothesis in boys' rule breaking behavior. This shows that the association between HR and ASB depends on age, gender, and subtype of ASB. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(5):493-502.