CD103 Manipulation Leads to T Regulatory Cells Upregulation (original) (raw)

Manipulation of CD103 through the M290 antibody enhances the upregulation of CD4+CD25+ T regulatory cells in naïve mice. This study investigates the kinetics of CD103 depletion and its associated immunological effects, demonstrating that both M290-SAP and its murinized form can induce T regulatory phenotypes without significant toxicity. The presence of alloantigen further potentiates the upregulation of these regulatory cells, suggesting a method for improving graft acceptance in transplantation contexts.