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Random Mutagenesis of Presenilin-1 Identifies Novel Mutants Exclusively Generating Long Amyloid β-Peptides
Georgia Dolios
Journal of Biological Chemistry, 2005
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A Pathogenic Presenilin-1 Deletion Causes Abberrant Aβ42 Production in the Absence of Congophilic Amyloid Plaques
Manuela Neumann
Journal of Biological Chemistry, 2000
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Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease
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EMBO molecular medicine, 2016
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Enhanced Production and Oligomerization of the 42-residue Amyloid beta -Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
Martin Citron
Journal of Biological Chemistry, 1997
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The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms
Xuefeng Xia
Proceedings of the National Academy of Sciences, 2002
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Cell-derived hexameric β-amyloid: a novel insight into composition, self-assembly and nucleating properties
Pierre Burguet
2020
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Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer’s Disease
Nazneen Dewji
PLOS ONE, 2015
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Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase
mary alice banks
Molecular and Cellular Neuroscience, 2009
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Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)
Sébastien Hébert
Neurobiology of Disease, 2003
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C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin
Akihiko Koyama
The Journal of Neuroscience, 1999
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Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
Ruth Perez
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An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β
Pascal Kienlen-Campard
Scientific Reports, 2021
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Inhibiting Amyloid Precursor Protein C-terminal Cleavage Promotes an Interaction with Presenilin 1
Erin Holmes
Journal of Biological Chemistry, 2000
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Effects of presenilin N-terminal fragments on production of amyloid β peptide and accumulation of endogenous presenilins
Takeshi Tabira
Neuroscience Letters, 1999
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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Grant Krafft
Trends in Neurosciences, 2001
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Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation
Minghao Zhong
Proceedings of the National Academy of Sciences, 2006
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Amyloid Aggregates, Presenilins, and Alzheimer's Disease
Ralf Baumeister
Angewandte Chemie International …, 1998
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Carboxyl-terminal Fragments of Alzheimer β-Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1-deficient Cells
Howard Mount
Journal of Biological Chemistry, 2000
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Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
Michael Lee
Neuron, 1997
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The aspartate-257 of presenilin 1 is indispensable for mouse development and production of -amyloid peptides through -catenin-independent mechanisms
Edward Ko
Proceedings of the National Academy of Sciences, 2002
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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid -protein generation
Michael Wolfe
Proceedings of The National Academy of Sciences, 2000
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The Influence of Endoproteolytic Processing of Familial Alzheimer's Disease Presenilin 2 on Aβ42 Amyloid Peptide Formation
Ralf Baumeister
Journal of Biological …, 1999
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Aβ aggregation and possible implications in Alzheimer's disease pathogenesis
Ashok Dubey
Journal of cellular …, 2009
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Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
Saketh Chemuru
Nature communications, 2016
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Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
Torleif Härd
Alzheimer's & Dementia, 2011
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Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2
Takeshi Tabira
European Journal of Neuroscience, 2004
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Modulation of beta-amyloid aggregation by engineering the sequence connecting beta-strand forming domains
Michael Hernandez
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
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Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling
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Frontiers in Cell and Developmental Biology
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Alzheimer disease: Amyloidogenesis, the presenilins and animal models
Morgan Newman, Ian Musgrave
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
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Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid β-Peptide Aβ42 in Late Compartments of the Constitutive Secretory Pathway
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Journal of Neurochemistry, 2008
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