Prevalence of Helicobacter pylori in patients with portal hypertensive gastropathy--a study from south India (original) (raw)
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Association of Helicobacter Pylori Infection with Portal Hypertensive Gastropathy in Liver Cirrhosis
The Medical Journal of Cairo University, 2018
Background: Portal hypertensive gastropathy (PHG) is an important cause of morbidity in patients with Liver cirrhosis (LC). Helicobacter pylori (HP) infection is a common cause of gastritis and is an endemic disease in Egypt. Aim of the Work: To study the presence of H. pylori infection in cases of LC with and without PHG. Material and Methods: Fifty patients with LC including 25 cases with PHG and 25 cases without PHG who attended Sohag Faculty Hospital during the period 9/2016-3/2017 were examined for the presence of H pylori infection histologically using Hematoxyline and Eosin and Geimsa stains. The correlation between H pylori infection and the severity of PHG was studied statistically. Results: H. pylori were detected in 76% of cases of LC (72% in LC with PHG and 80% of cases LC without PHG). Although there was an association between H pylori infection and the severity of PHG (5/7 cases), there was no statistically significant difference between H pylori infection and PHG. Conclusion: H. pylori infection can be seen in cases of LC irrespective of the presence or absence of PHG more than in general population.
Helicobacter pylori Infection in Congestive Gastropathy
Helicobacter, 1996
Background.This study determines the prevalence and significance of Helicobacter pylori infection in portal hypertensive patients. Materials and Methods.Patients numbered 118 and consisted of 90 patients with portal hypertension (66 men; 24 women; mean age, 49.1 ± 2.1 years) and 28 noncirrhotic patients with nonucler dyspepsia, (12 men; 16 women; mean age, 47.6 ± 2.8 years), who made up the control group. In all patients, diagnostic upper endoscopy was performed, and gastric biopsies were taken for histological examination and diagnosis of H. pylori. Results.Of the portal hypertensive patients, 42 (47%) had congestive gastropathy, 11 (26%) of whom were positive for H. pylori. and 48 (53%) did not have gastropathy, 12 (25%) of whom were positive for H. pylori. In the control group, 15 of 28 (54%) were positive for H. pylori. H. Pylori was found less frequently in congestive gastropathy patients than in the control group. We found also that the presence and severity of congestive gast...
Journal of Recent Advances in Medicine, 2021
Background: Cirrhosis is a great health problem worldwide and is associated with many complications. Portal hypertensive gastropathy (PHG) is one of its most common complications and in some patients may lead to gastrointestinal bleeding. The relationship between Helicobacter pylori (H. pylori) infection and PHG is not clearly identified. Objective: This work aimed to study a possible association between H. pylori infection and PHG and to correlate the severity of PHG with H. pylori infection in cirrhotic patients. Methodology: A cross sectional comparative study included 90 cirrhotic patients, who were classified into 3 groups. G1: included 30 age and sex-matched cirrhotic patients with no PHG. G2: included 30 age and sex-matched cirrhotic patients with mild PHG. G3: included 30 age and sex-matched cirrhotic patients with severe PHG. Endoscopic examination was done to evaluate the presence and severity of portal hypertensive gastropathy and for diagnosis of H. pylori infection. Results: H. pylori infection by histopathology was detected in 61 studied patients (67.8%). H. pylori infection was more prevalent among cirrhotic patients with PHG (78.3%) than patients without PHG (46.7%) (P=0.0029). H. pylori infection was detected in 26(86.7%), 21(70.0%), 14(46.7%) in patients with severe, mild and no PHG respectively. H. pylori infection was more prevalent in patients with severe PHG relative to patients with no PHG (p-value = 0.001). Conclusion: The current study showed a significant relation between H. pylori infection and PHG in cirrhotic patients and it might have a role in the pathogenesis of severe PHG.
National Journal of Medical Research, 2016
Introduction: In developing countries like India, Helicobacter pylori related gastritis is a major health ailment. This study was aimed to explore the prevalence of H. pylori infection in patients undergoing upper gastrointestinal endoscopy and its association with the various gastroduodenal diseases. Methods: This study cross sectional includes 158 patients both male and females patients attending Gastroenterology OPD at JSS Hospital, Mysuru with symptoms suggestive of gastro duodenal diseases. They were subjected to upper gastrointestinal endoscopy and investigated for H. pylori infection through histopathological examination. Data analysis was carried out using SPSS for Windows version 16.0. Results: Prevalence of H. pylori was more in male (78%) population compared to females (66%). Majority of the patients 97 (61.6%) out of 158 were in the age group of 31-60 yrs. Majority of H-pylori positive patients were found to be having H-pylori density 1+ (44.9%). Majority of patients was diagnosed to have duodenal ulcer (25.3%), gastric ulcer (21.5%) and gastric erosions (17.7%). Conclusion: From this study, we concluded that age related prevalence is more in relatively younger age group than elderly and prevalence is more in males. We also noticed that associations of H-pylori infection with gastric erosions and duodenal ulcers were statistically significant.
Introduction: Helicobacter pylori, a spiral shaped pathogenic bacterium found in the human gastric mucosa, It was first isolated by Warren and Marshall in 1982 (1) and soon after was linked with chronic antral gastritis and peptic ulceration. (2) The prevalence of Helicobacter pylori is variable in different parts of the world. It is more common in developing nations. Detection of H. pylori infection is done by different modalities. None of the testing methods are considered gold standard. The yield is higher if more than one modality is used. Aims and Objectives: To study the prevalence of Helicobacter pylori infection in patients of dyspepsia undergoing upper GI endoscopy by (a)-Rapid Urease Test (RUT) and (b)-Serology (IgG and IgM ELISA). Materials and Methods:182 patients undergoing Upper GI Endoscopy were screened for H. pylori infection using Rapid Urease Test (RUT) and serology (IgM and IgG ELISA
Journal of Gastroenterology and Hepatology, 1994
The spiral organism Helicobacter pylori has been causally implicated in the genesis of various gastroduodenal diseases. Since these diseases are common in southern India, this study was undertaken to determine the prevalence of H. pylori in the gastric mucosa of asymptomatic adults and patients with various gastroduodenal diseases. H. pylori was detected in the gastric mucosa of 25 of 30 (83.3%) normal volunteers.
International Journal of Advances in Medicine
Background: Helicobacter pylori (H. pylori) infection is a medical encumber especially in the developing countries, ranging from acute inflammation to malignancy. The study is intended to explore the prevalence of H. pylori infection and also to compute its associated risk factors.Methods: Sixty two (n=62) symptomatic patients attending the tertiary care hospital, were included in the study. Two antral biopsies collected from each patient were subjected to rapid urease test and Gram staining. IgG antibodies were detected by rapid test based on the principle of Immunochromatography. To evaluate the risk factors, various determinants were asked to each patient in the form of questionnaire. Statistical analysis was done using Fisher exact test. P value < 0.05 was considered significant.Results: Prevalence rate of H. pylori infection was 24.19 % (15/62). More than half (53%) of the infected patients had complained of persistent burning abdominal pain. Prevalence rate was found highes...
Journal of Lumbini Medical College, 2017
Introduction: Helicobacter pylori (H. pylori) related chronic gastritis is a major health problem worldwide, specially in the developing countries. The prevalence of H. pylori infection has been reported to vary between and even within countries. There are limited data on this infection in Western Nepal. Our objective was to study the prevalence of H. pylori infection and its association with presenting complains and upper gastrointestinal diseases. Methods: Medical records of patients undergoing gastrodudenoscopy and biopsy for various upper gastrointestinal symptoms from 1 st of January 2015 to 30 th of June 2017 were reviewed for presence of H. pylori infection, demographics, indications for gastrodudenoscopy, and histopathology findings. T-test, Chi-square test, and Fisher exact test were applied. Results: Two hundred fifty six patients (135 male and 121 female) with a mean age of 47 (SD = 16.5) underwent gastroscopic biopsy and had an overall H. pylori prevalence of 24.6%. H. pylori infection was most commonly noted between 41 to 60 years of age. Gender did not seem to be significantly associated (p = 0.82) but gastrointestinal bleed was significantly associated with H. pylori infection (p = 0.006). The most common histopathological diagnosis was gastritis followed by gastrodudenitis; however, none of the diagnosis were found to be significantly associated with H pylori infection. Conclusion: The overall prevalence of H pylori infection was 24.6% and was most common between 40 to 60 years of age. Heart burn was the most common symptom and gastrointestinal bleed was the only significantly associated symptom with H pylori infection.
2015
Background: Infection with Helicobacter pylori (H. pylori) is associated with significant morbidity and mortality. Till now, the seroprevalence of H. pylori infection from this part of India has not been reported. Aim: To study the seroprevalence of H. pylori infection in patients with gastrointestinal disorders undergoing upper gastrointestinal endoscopy at a tertiary care government setup. Settings and Design: It is a single hospital based, cross-sectional, prospective study. Materials and Methods: The demographic data, blood sample to detect presence of H. pylori IgG by ELISA and gastric biopsy specimen for rapid urease test (RUT) were collected from eighty (80) patients. Statistics: Data analysis was carried out with GraphPad InStat statistical program. Prevalence rates are expressed as percentages. Unpaired t test was used to compare the continuous variable. P value < 0.05 was taken to be statistically significant. Fischer exact test was used to analyze categorical data. Res...
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi, 2022
Objective: In our study, we aimed to evaluate the prevalence of Helicobacter pylori (H. Pylori) and the characteristics of antrum pathologies in patients with portal hypertensive gastropathy. Materials and Methods: Antrum pathologies and the presence of H. Pylori evaluated with Giemsa stain in gastroscopies of 203 patients with portal hypertensive gastropathy. Results: A total of 203 patients, 119 male, 84 female, with portal hypertensive gastropathy was included in our study. In patients with portal hypertension, the rate of H. Pylori positivity was 15.3%. This rate was determined as 18.5% under 65 years old and 8.8% over 65 years old. On the basis of gender, H. Pylori positivity rates were 21.8% in male patients and 6% in female patients. The most common antrum pathologies in the patients, in order of frequency, were reactive gastropathy with a rate of 41.4%, active gastritis with a rate of 23.6%, and edema with a rate of 22.2%. The rate of intestinal metaplasia was found to be 9.9%. Conclusion: In the patients with portal hypertension included in our study, the H. Pylori positivity rate was found to be 15.3%. This rate was found to be below the H. Pylori positivity rate in our country. The most common antrum pathology in the patients was reactive gastropathy with a rate of 41.4%, while the rate of intestinal metaplasia was found to be 9.9%.