The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma (original) (raw)

Polish journal of pathology : official journal of the Polish Society of Pathologists, 2007

Abstract

Hamartomas are the third most common cause of solitary pulmonary nodule and the most common benign tumors of lung. Recent study indicated that hamartoma may be associated with a chronic inflammatory diseases. Histochemical analysis of the expression profile of growth-relevant was shown the upregulation of macrophage migration inhibitory factor (MIF) in hamartomas and surrounding lung parenchyma. We investigated polymorphism G/C at position -173 promoter gene of MIF, pro-inflammatory cytokine in pulmonary hamartoma. This polymorphism of the MIF gene are association with increased production of MIF and have been found to confer increased risk of susceptibility to chronic inflammatory diseases. DNA samples were obtained from hamartoma tissue fixed with formalin, embedded in paraffin, from 52 patients and from blood samples of 123 sex and age matched healthy person served as control. The G/C polymorphism of MIF gene was determined by PCR-based AluI restriction fragment length polimorphi...

Andrzej Kulig hasn't uploaded this paper.

Let Andrzej know you want this paper to be uploaded.

Ask for this paper to be uploaded.