Prevalence of Hyposalivation in Patients with Systemic Lupus Erythematosus in a Brazilian Subpopulation (original) (raw)
Related papers
Zanjan University of Medical Sciences, 2023
Background and Objective: Due to the overall wide range of oral manifestations and the lack of comprehensively categorized information in Iran, this study was performed to investigate the prevalence of different oral manifestations and report their possible associated factors in patients with SLE. Materials and Methods: This cross-sectional study was performed on 96 SLE patients referred to two rheumatology clinics in Yazd, Iran, from September 2020 to February 2021. SLE patients were diagnosed based on the last revision of American College of Rheumatology (ACR) criteria in 1997. A questionnaire was created to collect demographic information and oral health status. Data were analyzed using SPSS v20.0 and p-values of P < 0.05 were considered statistically significant. Results: This study included 13 men (13.5%) and 83 women (86.5%), with an average age of 31.9 ±11.35 years. Oral lesions were diagnosed in 64.4% of patients, with white and red lesions being the most frequent (58%), and the most common region involved was buccal mucosa (25.8%). 97.1% of participants had caries and 86.5% had periodontal diseases. There was a significant association between the presence of oral lesions and female gender, longer duration and higher activity level of the disease and simultaneous presence of periodontal disease and missing or filled teeth. (P < 0.05). Conclusion: Given the frequency of oral lesions in more than 60% of patients, as well as the high incidence of caries and periodontal disorders, regular oral examinations in these patients appear to be particularly important. Keywords: Oral health, Oral lesions, Lupus Erythematosus
Oral Manifestation on Systemic Lupus Erythematosus Patients
International Journal of Public Health and Clinical Sciences, 2019
Background: Periodontitis worldwide reported increasing 57.3% between 20 years also reported 6 th most prevalence disease around the world. Imune response abnormalities, hyperactivity of production of autoantibodies deposited in human tissue and organ could affect oral cavity condition. Objectives: To find oral manifestation on SLE patients and correlate with SLE severity. Methods: Subjects were 61 patients with SLE (age 17-51 years; diagnosed using SLICC) collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Oral Manidestation is measured by clinical examination and SLE severity measured using SLEDAI. Result: A total 61 SLE subjects were included in this study. We found that 54 patients (88,53%) subjects with SLE had periodontitis. 7 subject had no periodontitis, 11 mild periodontitis, 43 severe periodontitis. There is correlation between oral condition and SLE severity. Periodontitis and SLEDAI score showed significant (p<0.0001) and strong positive correlation (r=0.948) Discussion : Our study found high rates of gingivitis, periodontitis, bop, low plaque index, and low calculus index. SLE is chronic autoimmune disease develop autoantibodies and immune complexes, because of immune respon abnormalities.It could be forming autoantibodies cause DNA damage, lipid peroxidation, protein. This condition induce collagen breakdown, RANKL, osteoclast stimulation until alveolar bone resorption resulting poor oral condition and periodontitis. Conclusion: Our study showed that oral condition were associated with SLE disease activity
Oral manifestations of systemic lupus erythematosus
British Journal of Oral and Maxillofacial Surgery, 1997
The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus (SLE) patients in Qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny. Methods. Study procedures took place between November 2014 and April 2016. All patients visiting the outpatient rheumatology clinics at Hamad General Hospital, Doha, Qatar, were asked to join. The American College of Rheumatology (ACR) 1997 criteria of SLE were used. The patients were examined initially by a rheumatologist and were later scheduled for an appointment with a dentist at the same institution. A total of 77 patients were recruited for the study. Results. Prevalence rates for the different oral manifestations ranged from 2.4% for soft palate ulcers, cheilitis, and oral candida to 88.1% for the presence of cavitation. Gingivitis, periodontal disease, cavities, and missing teeth were observed in more than 50% of the sample. The prevalence of periodontal disease and missing teeth was higher among those with an SLE duration > 8 years. On the contrary, the prevalence of gingivitis and cavities was higher among those with an SLE duration ≤ 8 years. Conclusion. This study found high rates of gingivitis, periodontal disease, cavities, and missing teeth among SLE patients in Qatar. It is recommended that healthcare providers of such patients monitor the presence of any oral manifestations in order to arrange for early treatment and prevention efforts. Future prospective longitudinal studies with adequate sample size and power are needed in order to ascertain any causation factors or common etiology pathways.
Oral Manifestation of Systemic Lupus Erythematosus
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017
Background: Periodontitis worldwide reported increasing 57.3% between 20 years also reported 6 th most prevalence disease around the world. Imune response abnormalities, hyperactivity of production of autoantibodies deposited in human tissue and organ could affect oral cavity condition. Objectives: To find oral manifestation on SLE patients and correlate with SLE severity. Methods: Subjects were 61 patients with SLE (age 17-51 years; diagnosed using SLICC) collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Oral Manidestation is measured by clinical examination and SLE severity measured using SLEDAI. Result: A total 61 SLE subjects were included in this study. We found that 54 patients (88,53%) subjects with SLE had periodontitis. 7 subject had no periodontitis, 11 mild periodontitis, 43 severe periodontitis. There is correlation between oral condition and SLE severity. Periodontitis and SLEDAI score showed significant (p<0.0001) and strong positive correlation (r=0.948) Discussion : Our study found high rates of gingivitis, periodontitis, bop, low plaque index, and low calculus index. SLE is chronic autoimmune disease develop autoantibodies and immune complexes, because of immune respon abnormalities.It could be forming autoantibodies cause DNA damage, lipid peroxidation, protein. This condition induce collagen breakdown, RANKL, osteoclast stimulation until alveolar bone resorption resulting poor oral condition and periodontitis. Conclusion: Our study showed that oral condition were associated with SLE disease activity
2015
Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue-binding auto antibodies and immune complexes. The treatment of SLE is highly individualized because of its diversity of clinical manifestations. Patients are treated according to the clinical manifestations they develop with different drugs like steroids, immunosuppressant's etc. The comorbidities which increase the risk of morbidity and mortality in SLE patients according to EULAR are infections, hypertension, dyslipidemia, atherosclerosis, coronary artery disease, diabetes mellitus, osteoporosis, avascular necrosis of bone, malignancies. One hundred and thirty two patients with SLE treated at Tertiary care Hospital, Nellore during October 2014-August 2015were collected from MRD. Among them 93 patients were enrolled into the study based on the inclusion and exclusion criteria. The demographic details of all patients admitted were presented in table 1. The mean age of 93 patients was 30.60 ± 8.83 years. The study population consisted of 87 females and 6 males (15:1.9) with an average age of 29.3±8.5 years at the onset of the disease. Gender wise distribution is presented in figure 1. 8.6% of the patients had a family history of the SLE. Among the various co-morbid conditions observed in SLE patient's hypertension was seen in 6.5% followed by hypothyroidism (5.4%).
Systemic Lupus Erythematosus: some Epidemiological and Clinical Aspects
American Journal of Public Health Research, 2015
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with a wide array of clinical manifestations including rash, photosensitivity, oral ulcers, arthritis, serositis, glomerulonephritis among others clinical findings. In this paper we globally summarized the most important epidemiological and clinical aspects to bear in mind, when the time comes to make the diagnosis of this rheumatic disorder and its management. Factor that are involved in the SLE pathogenesis and novel treatment options are mentioned.
Patients with Systemic Lupus Erythematosus
2016
A benefi cial infl uence of antimalarials on lipid profi le of systemic lupus erythematosus (SLE) patients has been recently claimed. In this cross-sectional study, we evaluated the effect of chloroquine on cholesterol levels of a Brazilian popu-lation with SLE. Sixty patients were studied, 95 % females. Mean age was 48.7 years (SD 13.3 years). Overweight or obesity was documented in 27 cases (45%). Thirty-four patients (56.6%) were using chloroquine in standard dosage, while 33 (55%) were on corticosteroids. Hypercholesterolemia was present in 26 patients (43.3%), while low HDL-cholesterol levels were seen in 18 cases (30%). Normal cholesterolemia was documented equally in users and non-users of antimalarials (P> 0.20). After adjustment for statin and corticosteroid intake by multivariate analysis, cholesterol and HDL-cholesterol levels did not signifi cantly differ in users or non-users of chloroquine (P> 0.05). There was no association of chloroquine intake with low body ma...
Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus
Revista de Chimie
Saliva is a remarkable diagnostic fluid being used to monitor a wide range of local and systemic diseases. Autoimmune diseases represent a major health threat to women worldwide with sexual hormones acting as co-factors for these pathologies and interfering with the normal immune response. The main aim of our study was to evaluate salivary levels of testosterone (T2) and 17-b estradiol (E2) in several autoimmune diseases with a special focus on systemic lupus erythematosus (SLE). The study included 45 SLE patients, 15 patients with other autoimmune diseases and 10 healthy subjects. Salivary T2 and E2 levels were determined using ELISA assays. Salivary E2 levels in female SLE patients were significantly increased versus vasculitis female patients. Positive correlations have been found between salivary E2 levels and important clinical parameters such as age at inclusion and duration of corticosteroid treatment. E2 salivary level was also identified as an independent predictor of lupus...
Salivary biomarkers of inflammation in systemic lupus erythematosus
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2018
Saliva is currently used as a reliable diagnostic fluid in a wide range of local and systemic diseases. However, the link between salivary diagnosis and the inflammatory process in autoimmune diseases has not yet been explored. The aim of our study is to assess possible correlations between salivary inflammatory markers and systemic lupus erythematosus (SLE). Patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) diagnosis criteria were included. Salivary and serum levels of interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) were determined using stochastic sensors. Serum leptin and IL-6 had significantly higher levels in SLE patients compared to non-SLE. Also, salivary IL-6 levels highly correlated with the serum IL-6 levels. A positive correlation was found between salivary and serum levels of IL-6, signaling salivary IL-6 as a reliable marker for assessing the inflammation process in SLE.