Burkitt's lymphoma: new insights into molecular pathogenesis (original) (raw)

Burkitt's lymphoma (BL) is classified into three main subcategories: endemic, non-endemic, and immunodeficiency-associated. The diversity in BL's molecular pathogenesis is highlighted, particularly the role of Epstein-Barr virus (EBV) in endemic BL versus the lower association in HIV-related cases. Key insights involve the common t(8;14) translocation driving c-myc overexpression, while other genetic alterations and environmental factors contribute to the complexity of BL's etiology and behavior.