Potential Role of the Chemokine Macrophage Inflammatory Protein 1  in Human and Experimental Schistosomiasis (original) (raw)

2005, Infection and Immunity

AI-generated Abstract

In human schistosomiasis, elevated levels of the chemokine macrophage inflammatory protein 1␣ (MIP-1␣/CCL3) in plasma correlate with the severity of the disease, especially in patients with hepatosplenic complications. This study confirms CCL3's role as a biomarker for severe schistosomiasis and investigates its potential pathogenic role through experiments in CCL3-deficient mice, which exhibited reduced granuloma size, lower worm burden, and altered immune response upon infection. Findings suggest that CCL3 may contribute to disease severity in schistosomiasis, highlighting its potential as a target for therapeutic intervention.

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