Parathyroid Hormone-induced Bone Resorption Does Not Occur in the Absence of Osteopontin (original) (raw)

Osteopontin plays a crucial role in the regulation of osteoclastic bone resorption, particularly in the context of parathyroid hormone (PTH) signaling. This study investigates the impact of osteopontin deficiency on bone resorption processes using organ culture systems. Results indicate that PTH fails to enhance bone resorption in osteopontin-deficient bones, in contrast to its effect on wild type bones, attributed to a reduction in osteoclast numbers and activity. The findings emphasize the importance of osteopontin in maintaining normal bone resorption dynamics in osteopenic diseases.