Vitamin D Deficiency, Smoking, and Lung Function in the Normative Aging Study (original) (raw)
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Vitamin D status and longitudinal lung function decline in the Lung Health Study
2011
Low blood vitamin D levels have been postulated to be a risk factor for worse lung function, based largely on cross-sectional data. We sought to use longitudinal data to test the hypothesis that baseline plasma 25-hydroxyvitamin D (25(OH)D) is lower in subjects with more rapid lung function decline, compared to those with slow lung function decline. We conducted a nested, matched case-control study in the Lung Health Study 3 cohort. Cases and controls were continuous smokers with rapid and slow lung function decline, respectively, over ,6 yrs of follow-up. We compared baseline 25(OH)D levels between cases and controls, matching date of phlebotomy and clinical centre. Among 196 subjects, despite rapid and slow decliners experiencing strikingly and significantly different rates of decline of forced expiratory volume in 1 s (-152 versus-0.3 mL?yr-1 ; p,0.001), there was no significant difference in baseline 25(OH)D levels (25.0 versus 25.9 ng?mL-1 ; p50.54). There was a high prevalence of vitamin D insufficiency (35%) and deficiency (31%); only 4% had a normal 25(OH)D level in the winter. Although vitamin D insufficiency and deficiency are common among continuous smokers with established mild-to-moderate chronic obstructive pulmonary disease, baseline 25(OH)D levels are not predictive of subsequent lung function decline.
Relationship of vitamin D status to adult lung function and COPD
2011
Background There is considerable interest in the possible role of vitamin D in respiratory disease, but only one population-based study has reported associations with lung function. Methods The cross-sectional relationships of total dietary vitamin D intake, serum 25 hydroxy vitamin D (25 (OH)D) concentrations and three vitamin D receptor (VDR) polymorphisms (Apa1, Fok1 and Cdx2) with lung function and spirometrically-defined chronic obstructive pulmonary disease (COPD) were investigated in men and women aged 59e73 years in the Hertfordshire Cohort Study, UK. Results After controlling for confounders, total vitamin D intake was positively associated with forced expiratory volume in 1 s (FEV 1 ; difference in FEV 1 between top and bottom quintiles of intake 0.079 l (95% CI 0.02 to 0.14), p trend¼0.007, n¼2942), ratio of FEV 1 to forced vital capacity (FEV 1 /FVC; p trend¼0.008) and negatively associated with COPD (OR comparing top and bottom quintiles 0.57 (95% CI 0.38 to 0.87), p trend¼0.02). In contrast, serum 25(OH)D concentrations were not related to FEV 1 (p trend¼0.89, n¼1197) but were positively associated with COPD (p trend¼0.046). VDR genotypes were unrelated to lung function and did not modify the effects of dietary intake or 25(OH)D concentrations on lung function. Conclusions The results of this study did not confirm a positive association between blood 25(OH)D concentrations and adult lung function. The apparent relationships with dietary vitamin D are likely to be explained by other highly correlated nutrients in the diet.
Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study
PloS one, 2014
Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population. We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death. There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, ...
Scientific Reports
Hypovitaminosis D has been linked to several non-bone diseases. Relation between 25-hydroxyvitamin D [25(OH)D] and lung function and lung diseases has received little attention at the global level. Cross-sectional data from three National Health and Nutrition Examination Surveys, 2007–2008, 2009–2010, and 2011–2012 were used to investigate the relationship between serum 25(OH)D concentrations and lung function makers [forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)] and lung diseases (asthma, emphysema, and chronic bronchitis) with multivariate regression models (n = 11,983; men, 6,010; women, 5,973). Serum 25(OH)D concentrations were directly associated with FVC and FEV1 (P for trend
BMC Pulmonary Medicine
Background Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods Current and former smokers between ages 45–80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was c...
Association of vitamin D status in the pathogenesis of chronic obstructive pulmonary disease
Egyptian Journal of Chest Diseases and Tuberculosis, 2015
Background: The most important pathogenic mechanisms involved in the development of chronic obstructive pulmonary disease (COPD) are protease-antiprotease imbalance, inflammation, lung remodeling and oxidative stress. Interestingly, lower vitamin D levels have been related to regulation of each of these processes, that is, higher expression of proteases, modulation of inflammation, modulation of extracellular matrix turnover, and increased oxidative stress. Thus, one can speculate that lower vitamin D levels may be linked to increased risk of developing COPD. In some clinical studies, lower levels of vitamin D, measured as plasma 25-hydroxyvitamin D (25(OH)D), have been associated with lower lung function and faster lung function decline, but the results are conflicting. Aim of the study: The aim of this study is to evaluate the evidence of the effect of vitamin D on COPD. Subjects and methods: The present study, included 120 subjects, 80 patients diagnosed as COPD and 40 healthy volunteers (20 smokers and 20 nonsmokers). Plasma 25-OHD was measured by Enzyme Linked Immunosorbent Assay (DiaSorin, Stillwater, Minnesota, USA) in all study participants. Results: The mean concentration of 25-OH-D was significantly higher in the reference groups (smokers and nonsmokers) compared with severe COPD group (p = 0.001, 0.001) respectively. The mean concentration of 25-OH-D was significantly higher in the reference groups (smokers and nonsmokers) compared with moderate COPD group (p = 0.029, 0.049) respectively. The mean concentration of 25-OH-D was not significantly higher in the reference groups (smokers and nonsmokers) compared with the mild COPD group.
Vitamin D Deficiency and the Lung: Disease Initiator or Disease Modifier?
Nutrients, 2013
Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including diseases of the respiratory system. These associations have largely been demonstrated epidemiologically and have formed the basis of the justification for a large number of clinical supplementation trials with a view to improving disease outcomes. However, the trials that have been completed to date and the ongoing experimental studies that have attempted to demonstrate a mechanistic link between vitamin D deficiency and lung disease have been disappointing. This observation raises many questions regarding whether vitamin D deficiency is truly associated with disease pathogenesis, is only important in the exacerbation of disease or is simply an indirect biomarker of other disease mechanisms? In this review, we will briefly summarize our current understanding of the role of vitamin D in these processes with a focus on lung disease.
Indian Journal of Respiratory care, 2022
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airway obstruction and impaired pulmonary function. Acute exacerbation is responsible for the majority of COPD mortality and morbidity. This study aimed to evaluate the association between serum Vitamin D deficiency and COPD exacerbation. Materials and Methods: This cross-sectional study was conducted on 80 COPD patients who were hospitalized for severe acute exacerbation in Imam Reza Hospital, Mashhad, Iran, in 2016–2017. Subjects were excluded if they were taking corticosteroid, calcium, phosphorus, or Vitamin D supplements. Immunocompromised patients and cases with underlying cardiovascular, liver, or renal diseases, metabolic syndrome, cancers, electrolyte imbalance, and any diseases related to Vitamin D metabolism and absorption were also excluded. A blood sample of 3 ml was taken from each participant to measure 25-hydroxyvitamin D (25OHD) level, up to 24 h after hospitalization. The severity of the disease was assessed by forced expiratory volume in 1 s obtained from spirometry tests, and hypoxemia level using O2 saturation. Results: The lower levels of mean serum 25OHD were significantly associated with the increased number of exacerbations (P = 0.01). Hypoxemia levels and the mean serum 25OHD level were found to have a significant association as well (P = 0.01). However, no significant relationship was observed between the mean serum 25OHD level and the duration of hospitalization (P = 0.1). Conclusions: Serum Vitamin D deficiency was associated with increased COPD exacerbation and poor clinical outcomes. Therefore, Vitamin D supplementation should be considered to reduce the risk of COPD exacerbation.
Association Between Vitamin D Status and COPD Phenotypes
Lung, 2014
Background It has been suggested that identifying phenotypes in chronic obstructive pulmonary disease (COPD) might improve treatment outcome and the accuracy of prediction of prognosis. In observational studies vitamin D deficiency has been associated with decreased pulmonary function, presence of emphysema and osteoporosis, upper respiratory tract infections, and systemic inflammation. This could indicate a relationship between vitamin D status and COPD phenotypes. The aim of this study was to assess the association between vitamin D levels and COPD phenotypes. In addition, seasonality of vitamin D levels was examined. Methods A total of 91 patients from a Danish subpopulation of the ''Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points'' cohort took part in a biomarker substudy. Vitamin D concentration was measured from blood samples taken at two visits, approximately 6 months apart. The participants were 40-75-year-old patients with COPD and had a smoking history of [10 pack-years. Results Fifty-six patients had 25-hydroxyvitamin D measured from blood samples from both visits. In the final model of the multivariate analyses, the factors that were associated with vitamin D deficiency at the first visit were age (OR: 0.89, p = 0.02) and summer season (OR: 3.3, p = 0.03). Factors associated with vitamin D level also at the first visit were age (B: 0.9, p = 0.02) and 6 min walking distance (B: 0.05, p = 0.01). Conclusion Vitamin D was not associated with COPD phenotypes and season did not seem to be a determinant of vitamin D levels in patients with moderate to severe COPD.