Marine Peptides As Anticancer Agents: A Remedy To Mankind By Nature (original) (raw)

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks. The structural characteristics of these peptides include various unusual amino acid residues which may be responsible for their bioactivity. Moreover, protein hydrolysates formed by the enzymatic digestion of aquatic and marine by-products are an important source of bioactive peptides. Purified peptides from these sources have been shown to have antioxidant activity and cytotoxic effect on several human cancer cell lines such as HeLa, AGS, and DLD-1. These characteristics imply that the use of peptides from marine sources has potential for the prevention and treatment of cancer, and that they might also be useful as molecular models in anticancer drug research. This review focuses on the latest studies and critical research in this field, and evidences the immense potential of marine animals as bioactive peptide sources.

IJSRST1622111 | A Review on Anticancer Drug from Marine

The marine environment is a rich source of both biological and chemical diversity. It is very much likely that marine organisms would be wonderful source of biologically active molecules The collection of the marine therapeutics includes molecules with antibiotic, antiviral, antiphrastic, analgesic and anticancer agent from bacteria, cyanobacteria, tunica, fungi, sponge This reviewfocuses on the latest studies and critical research in this field and evidences the immense potential ofmarine organisms as sources of bioactive peptides and other anticancer biomolecules Various anticancer compounds like Aplidine, Bryostatin-1, Didemin B, Dolastation, Ecteinascidine with diverse modes of action, such as, anti-proliferative, antioxidant, anti-microtubule havebeen isolated from marine sources. Traditional chemotherapeutic agents have a range of side effects likefatigue, gastrointestinal distress and depression of immune system which introduces the these sources have been shown to have antioxidantactivity and cytotoxic effect on several human cancers such as leukemia, lymphoma, ovarian, melanoma, breast, bladder, neuroendocrine, prostatic, colon and non-small cell lung cancer very potently.

A Review on Anticancer Drug from Marine

The marine environment is a rich source of both biological and chemical diversity. It is very much likely that marine organisms would be wonderful source of biologically active molecules The collection of the marine therapeutics includes molecules with antibiotic, antiviral, antiphrastic, analgesic and anticancer agent from bacteria, cyanobacteria, tunica, fungi, sponge This reviewfocuses on the latest studies and critical research in this field and evidences the immense potential ofmarine organisms as sources of bioactive peptides and other anticancer biomolecules Various anticancer compounds like Aplidine, Bryostatin-1, Didemin B, Dolastation, Ecteinascidine with diverse modes of action, such as, anti-proliferative, antioxidant, anti-microtubule havebeen isolated from marine sources. Traditional chemotherapeutic agents have a range of side effects likefatigue, gastrointestinal distress and depression of immune system which introduces the these sources have been shown to have antioxidantactivity and cytotoxic effect on several human cancers such as leukemia, lymphoma, ovarian, melanoma, breast, bladder, neuroendocrine, prostatic, colon and non-small cell lung cancer very potently.

Marine natural products as anticancer drugs

Molecular cancer therapeutics, 2005

The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.

Biological Potential of Various Marine Peptides: A Review

2019

Marine organisms are important sources of bioactive molecules that have been used to treat various diseases. Unusual marine environments are associated with chemical diversity, leading to a resource of novel active substances for the development of bioactive products. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various activities, such as antimicrobial, antifungal, antidiabetic, antitumor, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. In this review, we will present the structures and activities of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish).

Bioactive Peptides from Marine Sources-A Review

Marine organisms represent a valuable source of new compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active substances in the field of the development of bioactive products. In this paper, the molecular diversity of different marine peptides is described as well as information about their biological properties and mechanisms of action is provided. Moreover, a short review about isolation procedures of selected bioactive marine peptides is offered. Novel peptides from sponges, ascidians, mollusks and seaweeds are presented in association with their pharmacological properties and obtainment methods.

Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic st...

Bioactive peptides from marine sources: pharmacological properties and isolation procedures

Journal of Chromatography B, 2004

Marine organisms represent a valuable source of new compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active substances in the field of the development of bioactive products. In this paper, the molecular diversity of different marine peptides is described as well as information about their biological properties and mechanisms of action is provided. Moreover, a short review about isolation procedures of selected bioactive marine peptides is offered. Novel peptides from sponges, ascidians, mollusks, sea anemones and seaweeds are presented in association with their pharmacological properties and obtainment methods.