Spectrum of Anti Citrullinated Peptide Antibodies (ACPA) fine specificities is different between Malaysian and Swedish rheumatoid arthritis patients: Implications for pathogenesis of RA (original) (raw)

2016, Arthritis & rheumatology (Hoboken, N.J.)

Antibodies to the citrullinated protein antigens (ACPA) are important in the diagnosis and pathogenesis of rheumatoid arthritis (RA). However, the prevalence of ACPAs with different specificities in different populations is unclear. We report the fine specificity of the antibody responses towards citrullinated proteins in RA patients from Malaysia, an area where genetic and environmental determinants of RA are different from those in the more frequently studied Caucasians. A multiplex analytic microarray system was used to analyze the occurrence of antibodies to 10 different citrullinated peptides [filaggrin (fil307-324), vimentin (Vim2-17, Vim60-75), fibrinogen (Fibα563-583, Fibα580-600, Fibβ36-52, Fibβ62-81a, Fibβ62-81b), enolase (Eno5-21) and collagen type II (citCII355-378)] in 4,089 RA serum samples (1,231 Malaysian and 2,858 Swedish) and 827 normal controls samples (249 Malaysian and 578 Swedish). The positive reaction threshold was set for each population with each peptide se...

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