Collision of two epidemics: prevalence of diabetes in tuberculosis patients in urban Ludhiana (original) (raw)
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Journal of family medicine and primary care
Tuberculosis (TB) and diabetes mellitus (DM) remains a worldwide global public health problem. About 95% of patients with TB live in the low and middle-income countries and more than 70% of patients with DM also live in the same countries, especially in South East Asia. Screening for diabetes in patients with TB will not only ensure early case detection but also better management of diabetes and will lead to better TB treatment outcome. This study aims to determine the prevalence and its associated factors of diabetes and prediabetes among diagnosed cases of TB patients registered under Revised National Tuberculosis Control Programme (RNTCP) in Bhopal city. The current study was a longitudinal follow-up study conducted among registered TB patients under RNTCP in all 5 TB units of Bhopal District. Participants were contacted and interview was conducted after obtaining consent using predesigned and pretested Performa during October 2013-September 2014. Continuous variable were summari...
Prevalence of diabetes mellitus among tuberculosis patients in Urban Puducherry
North American Journal of Medical Sciences, 2014
Background: Diabetes and Tuberculosis often present together and complicate each other at many levels. A collaborative framework for care and control of diabetes and tuberculosis developed by World Health Organisation and International Union against Tuberculosis and Lung Diseases emphasizes routine bi-directional screening for the two diseases. Aims: The study was to assess the prevalence of diabetes in tuberculosis patients currently on treatment. Materials and Methods: This facility-based cross-sectional study was undertaken in four randomly selected peripheral health institutions providing directly observed treatment short-course, treatment for tuberculosis patients. All cases of tuberculosis, more than 18 years of age were screened for diabetes. Risk factors like age, sex, family history of diabetes, alcohol, smoking and obesity were assessed. Results The prevalence of diabetes in tuberculosis patients was found to be 29% (known diabetics -20.7%, new Diabetes cases -8.3%). Diabetes was signifi cantly associated with older age, family history of diabetes, consumption of alcohol and sputum positivity. Conclusions: Screening patients with Tuberculosis for fasting blood sugar estimation will help in early detection of diabetes
PLoS ONE, 2012
Background: Diabetes mellitus (DM) is recognised as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. There are inadequate data on prevalence of DM and pre-diabetes among TB cases in India. Aim was to determine diabetes prevalence among a cohort of TB cases registered under Revised National Tuberculosis Control Program in selected TB units in Tamil Nadu, India, and assess pattern of diabetes management amongst known cases. Methods: 827 among the eligible patients (n = 904) underwent HbA1c and anthropometric measurements. OGTT was done for patients without previous history of DM and diagnosis was based on WHO criteria. Details of current treatment regimen of TB and DM and DM complications, if any, were recorded. A pretested questionnaire was used to collect information on sociodemographics, habitual risk factors, and type of TB. Findings: DM prevalence was 25.3% (95% CI 22.6-28.5) and that of pre-diabetes 24.5% (95% CI 20.4-27.6). Risk factors associated with DM among TB patients were age (31-35, 36-40, 41-45, 46-50, .50 years vs ,30 years) [OR (95% CI) 6.75
International Journal of Research in Medical Sciences, 2022
Background: Diabetes (DM) can worsen the clinical course of tuberculosis (TB) and treatment outcomes in terms of increased deaths, treatment failure, and relapse rates. This study investigated the prevalence of DM in TB patients at an urban primary health centre (UPHC), Delhi and the factors associated with it. Methods: A record-based study of all TB patients registered from December 2019 to November 2020 at a directly observed treatment short-course (DOTS) center of a UPHC in Delhi was conducted. Information regarding sociodemographic details and disease profile, diabetes status and random blood sugar level was collected from patients' treatment cards. Data were entered and analyzed in SPSS. Descriptive analysis was done. Results: A total of 252 patients were registered at the DOTS center during one year and data for all of them were analyzed. The mean age of the study participants at the time of the study was 31.13±15.84 years, half of them were males (56%) and the site of the disease was predominantly pulmonary (61%). Out of 252 TB patients, 17 (7%) and 2 (1%) were diabetics and pre-diabetics respectively. Conclusions: Those patients with age more than 30 years, pulmonary TB, sputum positive TB are the factors with statistically significant association with diabetes in our study.
PLOS ONE
Background India has a high prevalence of tuberculosis (TB) as well as diabetes mellitus (DM). DM is a chronic disease caused by deficiency of insulin production by the pancreas. The risk of TB amongst DM patients is three times higher than those without. The estimated national prevalence of DM is 7.3%. Despite the growing burden of DM, there are limited studies describing the prevalence of TB-DM in India. Objective Our study estimated the prevalence of DM amongst adult hospitalized TB patients at Kasturba Hospital, Manipal and determined factors associated with the likelihood of DM-TB coprevalence. Methods We conducted a retrospective cohort study at Kasturba Hospital, Manipal Academy of Higher Education. All hospitalized adult patients diagnosed with pulmonary TB (PTB) and extrapulmonary TB (EPTB) between June 1 st 2015 and June 30 th 2016 were eligible for inclusion. Pediatric and pregnant TB patients were excluded from our study. Data were extracted from medical charts. Descriptive and multivariate analyses were performed in R. Multivariate analysis adjusted for age, gender, type of TB, history of TB, and nutrition (body mass index (BMI)) status. Results A total of 728 patients met the eligibility criteria, 517 (71%) were male, 210 (29%) female, 406 (56%) had PTB and 322 (44%) had EPTB. Amongst those with a nutritional status, 36
2014
Recently several publications have been pronounced the relationship among Diabetes mellitus and tuberculosis patients, certainly the rise in the frequency of dynamic Diabetes mellitus in patients with tuberculosis and due to minor cure leading in Diabetes mellitus patients compared to those having no diabetic disorder. This research study was accompanied in the outpatient clinic shortened directly observed therapy (DOTS) center Kohat. Diabetes mellitus 1 Corresponding author: dr.nafisa.tahir@gmail.com Nafisa Batool Tahir, Qazi Tahir Uddin, Syed Sajid Munir, Abdul Waheed, Saqib Waheed, Hidayatullah, Muhammad DaudPrevalence of Diabetes Mellitus in tuberculosis patients at DOTS regional centre KMU-IMS teaching Hospital Kohat EUROPEAN ACADEMIC RESEARCH Vol. II, Issue 7 / October 2014 9949 individualls were arbitrarily selected by simple random sampling technique, the history and risk factors were collected through consent Questionnaire and blood samples were collected by nurse and were ...
Diabetes mellitus among tuberculosis patients in a tertiary care hospital of Lahore
Journal of Ayub Medical College, Abbottabad : JAMC
Diabetes is an important risk factor for Tuberculosis (TB) that might affect disease presentation and treatment response but has hitherto been neglected by the clinicians. There is inadequate data on the prevalence of diabetes mellitus (DM) among TB patients in Pakistan. This study was conducted to determine the frequency of TB patients having DM. In this cross-sectional study, 158 TB patients admitted in Gulab Devi hospital were selected by systematic random sampling technique and data were collected using a pretested questionnaire. All patients underwent anthropometric measurements and baseline investigations. Diabetes was confirmed by determining fasting blood sugar level using cut-off value of 126 mg/dl. Data was entered in Epi-Data-6 and analyzed using Epi-Info. Among 158 patients of tuberculosis, 41 (25.9%) were found to be diabetic, out of which 9 (5.69%) were newly diagnosed with diabetes. Moreover 96 (60.8%) patients were 35-55 years of age. Male patients were 97 (61.4%). M...
Journal of Dr. NTR University of Health Sciences, 2021
Background: In India, there was an estimated 2.69 million new tuberculosis (TB) cases with 449,700 deaths in 2018 and it continues to be a major public health problem. Diabetes mellitus (DM) and poor glycemic control triple the risk of TB and adversely affect TB treatment outcomes. This study aimed to determine the risk of type 2 DM among TB patients registered under RNTCP using the Indian Diabetes Risk Score (IDRS). Materials and Methods: This was a community-based cross-sectional study conducted among 60 TB patients of rural field practice area of a medical college. A pretested semi-structured questionnaire with IDRS was used for the data collection. TB patients were categorized into low-risk, medium-risk, and high-risk categories of developing diabetes using the IDRS. Necessary statistical tests like simple proportions and Chi-square test were applied to test for association between categorical variables. Results: Of 60 TB patients, 19 (31.7%) were in high-risk category; 36 (60%) were in the medium risk category and 5 (8.3%) were in low-risk category of developing DM. Conclusion: Routine DM screening of TB patients in the community using IDRS is the most cost-effective tool where there are limited resources and infrastructure and also provides an early opportunity to decrease the twin burden of TB-DM.
High Diabetes Prevalence among Tuberculosis Cases in Kerala, India
2012
Background: While diabetes mellitus (DM) is a known risk factor for tuberculosis, the prevalence among TB patients in India is unknown. Routine screening of TB patients for DM may be an opportunity for its early diagnosis and improved management and might improve TB treatment outcomes. We conducted a cross-sectional survey of TB patients registered from June-July 2011 in the state of Kerala, India, to determine the prevalence of DM. Methodology/Principal Findings: A statewide representative sample of TB patients in Kerala was interviewed and screened for DM using glycosylated hemoglobin (HbA1c); patients self-reporting a history of DM or those with HbA1c 6.56.5% were defined as diabetic. Among 552 TB patients screened, 243(44%) had DM-128(23%) had previously known DM and 115(21%) were newly diagnosed-with higher prevalence among males and those aged .50years. The number needed to screen(NNS) to find one newly diagnosed case of DM was just four. Of 128 TB patients with previously known DM, 107(84%) had HbA1c 6.57% indicating poor glycemic control. Conclusions/Significance: Nearly half of TB patients in Kerala have DM, and approximately half of these patients were newly-diagnosed during this survey. Routine screening of TB patients for DM using HbA1c yielded a large number of DM cases and offered earlier management opportunities which may improve TB and DM outcomes. However, the most costeffective ways of DM screening need to be established by futher operational research.
Incidence of Tuberculosis in Diabetic patients in Kolkata, India – a pilot study
Background & Objective – Tuberculosis (TB) and diabetes two of the most prevalent diseases worldwide and may occur concurrently. The association between TB & diabetes are known historically though from 18 th century onwards it is being studied in a more scientific manner. The objective of this study is to determine incidence of TB in diabetic patients and also to understand comorbid correlation. Materials & Methods-This is a retrospective cross sectional study carried out at the Respiratory medicine department of Medical College between November 2017 and December 2017. Results – Overall incidence of TB in diabetic patients was found to be 8.33%. Incidence rate of TB in Type I diabetes was 34.28% and in Type II diabetes was 8.49% (odds ratio 5.25). Fever as a presenting feature found to be more common in diabetic tuberculosis group (odds ratio 6.8333, 95% C.I 1.6535 to 28.2403, p = 0.0079). Diabetic tuberculosis group is more prone to develop cough in comparison to patients with only diabetes (Odds ratio 11.1724, 95% C.I 2.24 to 55.699, p= 0.0032). Chest pain, Respiratory distress and Haemoptysis are also more common in diabetic tuberculosis group (Odds ratio of 5.25, 153 and 6.66 respectively). Study results also showed that diabetic patient with TB have worse glycaemic control compared to patients suffering from only diabetes (Odds ratio 9.75, 95% C.I 1.9622 to 48.4476, p = 0.0054). Conclusion – TB and diabetes are both prevalent in Kolkata. In our country, large scale prospective cohort studies are needed to understand this relationship more vividly to develop better management protocols in future.